Abstract: A glassy carbon electrode was modified with graphene by casting. The modified electrode showed an excellent electrocatalytical effect on the oxidation of acetaminophen(ACOP). The voltammetric behavior and electrochemical analysis method of ACOP were studied on the modified electrode. The effect of pH value on the response of ACOP was studied in phosphate buffer solution(PBS). The results showed that the redox peak potential of ACOP shifted negatively with increasing pH value, and a pair of well-defined redox waves were obtained in PBS of pH=6.0. The oxidation peak currents of ACOP increased linearly with the concentration, in the range of 6.00×10-7~4.00×10-5 mol/L, the linear regression equation was ipa(A)=3.00c+1.21×10-5, with correlation coefficient 0.9940. The detection limit(S/N=3) was 5.00×10-8 mol/L. The graphene modified electrode showed a good sensitivity, selectivity and stability. It was applied to the ACOP tablets analysis.

Key words: hemically modified electrode, graphene, acetaminophen