Synthesis、Magnetism and Cancer-Inhibiting Activity of μ-4-Nitrophthalato Binuclear Cobalt(Ⅱ) Complexes

Chinese Journal of Applied Chemistry ›› 1996, Vol. 0 ›› Issue (4): 86-88.

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Synthesis、Magnetism and Cancer-Inhibiting Activity of μ-4-Nitrophthalato Binuclear Cobalt(Ⅱ) Complexes

Shi Jingmin, Liao Daizheng, Cheng Peng, Miao Mingming, Jiang Zonghui, Liu Yongjiang, Wang Genglin

Department of Chemistry, Nankai University, Tianjin 300071

Received:1995-10-30 Revised:1996-04-09 Published:1996-08-10 Online:1996-08-10

Abstract

Abstract: Two new novel binuclear cobalt (Ⅱ) complexes, namely,[Co₂ (4PT) (Phen)₄]( ClO₄ )₂· 3H₂O (complex 1) and[Co₂ (4PT)(NPhen)₄] (ClO₄)₂·2H₂O (complex 2) (4PT=4-nitrophthalato, Phen=l,10-phenanthroline, NPhen = 5-nitro-1,10-phenanthroline) have been synthesized. The complexes were characterized by elemental analysis, IR, UV-Vis spectra and electronic conductance. The variable-temperature magnetic susceptibility of the complexes was measured over 77～300 K. The data were analyzed by using the magnetic susceptibility equation based on Heisenberg spin-exchange operator, and the exchange integrals for complex 1 and complex 2 were found 2J= - 8.6 cm^-1 and 2J=-4.3 cm^-1,respectively. Experiments of inhibiting human leukemia cell, stomach cancer cell and carcinoma of nasopharyngeal cancer cell in vitro were made,and found that the complexes exhibited a relatively strong function of inhibiting these three kinds of cancer cells.

Key words: nitrophthalate, binuclear Co(Ⅱ) complex, magnetism, bioactivity

Shi Jingmin, Liao Daizheng, Cheng Peng, Miao Mingming, Jiang Zonghui, Liu Yongjiang, Wang Genglin. Synthesis、Magnetism and Cancer-Inhibiting Activity of μ-4-Nitrophthalato Binuclear Cobalt(Ⅱ) Complexes[J]. Chinese Journal of Applied Chemistry, 1996, 0(4): 86-88.

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Synthesis、Magnetism and Cancer-Inhibiting Activity of μ-4-Nitrophthalato Binuclear Cobalt(Ⅱ) Complexes

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