Preparation and Bioactivity for Inducing Bone Growth of Hydroxyapatite/Fe2O3 Composite Coating

doi:10.3724/SP.J.1095.2013.20559

Chinese Journal of Applied Chemistry

• Full Papers • Previous Articles Next Articles

Preparation and Bioactivity for Inducing Bone Growth of Hydroxyapatite/Fe₂O₃ Composite Coating

LI Longzhu, HUANG Ziyang^*, LIN Yan, CAO Mei, LIN Jianqun

(College of Chemistry and Chemical Engineering,Fujian Normal University,Fuzhou 350007,China)

Received:2012-12-03 Revised:2013-02-19 Published:2013-10-10 Online:2013-10-10
Contact: HUANG Ziyang

Abstract

Abstract: Electrophoretic deposition(EPD) has been exploited for the preparation of hydroxyapatite/chitosan/ferric oxide(HA/CS/Fe2O3) composite coating, which was then sintered at 700 ℃ for 2 h to yield HA/Fe2O3 composite coating. The surface morphology, phase composition, corrosion resistance and adhesion between the composite coating and substrate were characterized by SEM, EDS and XRD, FT-IR, electrochemical instrument and Lloyd LR5K Plus Testing Instrument, respectively. The bioactivity for inducing bone growth of the HA/Fe2O3 composite coating was evaluated in 1.5 times of ionic concentration of simulated body fluid(1.5SBF). When the mass ratio of HA∶CS∶Fe2O3 in the suspension was 100∶100∶1, the resultant HA/Fe2O3 composite coating had rough surface and strong adhesion up to 27.5 MPa with substrate and showed high corrosion resistance in 1.5SBF and excellent bioactivity for inducing bone growth in 1.5SBF.

Key words: hydroxyapatite/Fe2O3 composite coating, electrophoretic deposition, bioactivity

CLC Number:

LI Longzhu, HUANG Ziyang*, LIN Yan, CAO Mei, LIN Jianqun. Preparation and Bioactivity for Inducing Bone Growth of Hydroxyapatite/Fe₂O₃ Composite Coating[J]. Chinese Journal of Applied Chemistry, DOI: 10.3724/SP.J.1095.2013.20559.

References

[1] WANG Wenjing,HUANG Jianfeng,LI Yinghua,et al. Theoretical Research and Progress of Basal Body and Bio-coatings in Biomaterial Filed[J]. J Clin Rehab Tissue Eng Res,2010,14(3):30-33(in Chinese).

王文静,黄剑锋,李颖华,等. 生物材料中基体及涂层材料的研究与进展[J]. 中国组织工程研究与临床康复,2010,14(3):30-33.

[2] He X,Huang X,Lu Q,et al. Nanoscale Control of Silks for Regular Hydroxyapatite Formation[J]. Progress Nat Sci:Mater Int,2012,22(2):115-119.

[3] Li D,Wang W,Guo R,et al. Restoration of Rat Calvarial Defects by Poly(lactide-co-glycolide)/hydroxyapatite Scaffolds Loaded with Bone Mesenchymal Stem Cells and DNA Complexes[J]. Chinese Sci Bull,2012,57(5):435-444.

[4] SUN Baoguo,CHEN Fengbao,ZHAI Fuying,et al. Determination of the Contents of Traceelements in Human Bones[J]. Henan Med Res,1997,6(2):100-101(in Chinese).

孙保国,陈凤苞,翟福英,等. 人体骨骼中微量元素的测定[J]. 河南医学研究,1997,6(2):100-101.

[5] Wu T ,Nan K,Chen J,et al. A New Bone Repair Scaffold Combined with Chitosan/hydroxyapatite and Sustained Releasing Icariin[J]. Chinese Sci Bull,2009,54:2953-2961.

[6] YU Rong,FENG Bo,WANG Jianxin,et al. Protein-hydroxyapatite Composite Coatings on TiO2 Nanotube Layers and Bond Strength to Substrate[J]. Chinese J Inorg Mater,2011,26(9):987-992(in Chinese).

于榕,冯波,汪建新,等. TiO2纳米管表面蛋白质-羟基磷灰石复合涂层及其结合强度[J]. 无机材料学报,2011,26(9):987-992.

[7] LI Zhihong,WU Jimin,HUANG Shujie,et al. Preparation and Property of Strontium-substituted Hydroxyapatite[J]. Chinese J Inorg Mater,2011,26(1):49-54(in Chinese).

李志宏,武继民,黄姝杰,等. 掺锶羟基磷灰石的制备与性能研究[J]. 无机材料学报,2011,26(1):49-54.

[8] Wei Z J,Wang C Y,Zou S W,et al. Fe2O3 Nanoparticles as Particulate Emulsifier:Preparation of Magnetic and Biocompatible PLGA Microcapsules[J]. Colloids Surfaces A:Physicochem Eng Aspects,2011,392(1):116-123.

[9] Li G D,Feng S Y,Zhou D L. Magnetic Bioactive Glass Ceramic in the System CaO-SiO2-P2O5-MgO-Fe2O3 for Hyperthermia Treatment of Bone Tumor[J]. J Mater Sci:Mater Med,2011,22(10):2197-2206.

[10] LIU Rongfang,XIAO Xiufeng,NI Jun,et al. Study on Kinetics of Hydrothermal Synthesis of Hydroxyapatite Powders[J]. Chinese J Inorg Chem,2003,19(10):1079-1084(in Chinese).

刘榕芳,肖秀峰,倪军,等. 羟基磷灰石粉末的水热合成及动力学研究[J]. 无机化学学报,2003,19(10):1079-1084.

[11] ZHANG Lan,HUANG Ziyang. Fabrication and Bioactivity of Porous Hydroxyapatite Coating by Electrophoretic Deposition Using Different Porogens[J]. Chinese J Appl Chem,2012,29(1):46-50(in Chinese).

张岚,黄紫洋. 造孔剂对电沉积制备多孔HA涂层及其生物活性的影响[J]. 应用化学,2012,29(1):46-50.

[12] HUANG Ziyang,ZHANG Lan,LIANG Guangchao. Study on Fabrication and Properities of Porous HA/SiO2 Composite Coating on Tiatanium Substrate[J]. Acta Chim Sin,2012,70(3):235-240(in Chinese).

黄紫洋,张岚,梁广超. 钛基多孔HA/SiO2复合涂层的制备及其性能研究[J]. 化学学报,2012,70(3):235-240.

[13] XIAO Xiufeng,LIU Rongfang,ZHANG Xiaoqin,et al. Study on Hydrothermal Synthesis of Nanosized Hydroxyapatite Powders[J]. Inorg Chem Ind,2004,36(3):16-18(in Chinese).

肖秀峰,刘榕芳,张晓勤,等. 水热合成纳米羟基磷灰石粉体的研究[J]. 无机盐工业,2004,36(3):16-18.

[14] LI Shengchun,CHEN Pei,LI Yaogang. Influence of Fe2O3-dop on Thermal Property of ZnO-B2O3-P2O5-RnOm Glass System[J]. New Chem Mater,2011,39(7):114-116,133(in Chinese).

李胜春,陈培,李耀刚. Fe2O3掺杂对ZnO-B2O3-P2O5-RnOm玻璃热力学性能的影响[J]. 化工新型材料,2011,39(7):114-116,133.

[15] HUANG Yong,CAO Yu,HE Congjun,et al. The Present Situation of Hydroxyapatite/ZrO2 Bioactive Composite Coating[J]. Life Sci Instrum,2010,8:30-33(in Chinese).

黄勇,曹郁,和从军,等. 羟基磷灰石/氧化锆生物活性复合涂层的研究[J]. 生命科学仪器,2010,8:30-33.

[16] LI Zhouxin,WU Yongzhi,HE Dingyong,et al. Micro-plasma Sprayed Zirconia Reinforced Hydroxyapatite Composite Coatings[J]. Trans China Weld Inst,2008,29(6):1-4(in Chinese).

栗卓新,吴永智,贺定勇,等. 微束等离子喷涂氧化锆增韧羟基磷灰石复合涂层[J]. 焊接学报,2008,29(6):1-4.

[17] Ni S Y,Chang J,Chou L. A Novel Bioactive Porous CaSiO3 Scaffold for Bone Tissue Engineering[J]. Biomed Mater Res A,2006,76(1):196-205.

[18] Na Y,Chen S,Ouyang Y,et al. Bomimetic Mineralization Synthesis of Hydroxyapatite Bacterial Cellulose Nanocomposites[J]. Prog Nat Sci:Mater Int,2011,21:472-477.

[19] Li P,Kanagasnie I,Degroot K,et al. Bone Like Hydroxyapatite Induction by a Gel-derived Titania on a Titanium Substrate[J]. J Am Ceram Soc,1994,77(5):1307-1312.

[20] Kokubo T,Kim H M,Kawashita M,et al. Bioactive Metals:Preparation and Properties[J]. J Mater Sci:Mater Med,2004,15(2):99-107.

Preparation and Bioactivity for Inducing Bone Growth of Hydroxyapatite/Fe₂O₃ Composite Coating

PDF

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments

[1]	QIAN Cunwei, HUANG Haijun, FEI Zhenghao, ZHANG Yuqing, WANG Dong, ZONG Qianshou. Synthesis and Bioactivity of New 1,2,4-Triazole Compounds Containing Thiazole and Thioether [J]. Chinese Journal of Applied Chemistry, 2015, 32(4): 399-404.
[2]	ZHENG Yuguo ,GUO Qingqing,ZHOU Li,LI Shijie,YU Zhonglin,LIU Cuiju,XIONG Xiang. Synthesis and Biological Activity of Novel 1,2,4-Triazolothiadiazine Derivatives Containing Pyrazole Unit [J]. Chinese Journal of Applied Chemistry, 2015, 32(2): 151-157.
[3]	LI Yuanxiang1,2*, CHEN Dizhao1. Synthesis and Biological Activities of N-(2-(Cyano(4,6-dimethoxypyrimidin-2-yl)methyl)phenyl) Substitued Amide Derivatives [J]. Chinese Journal of Applied Chemistry, 2013, 30(09): 999-1004.
[4]	GAO Shukun*, SHI Ying, HAN Zongling, FU Haifeng, XU Liangzhong, CHEN Xiaotao. Synthesis and Acaricidal Activity of Carboxylate Derivatives of Tetronic Acid Compounds [J]. Chinese Journal of Applied Chemistry, 2012, 29(08): 885-891.
[5]	ZHENG Yuguo1,2, GUO Qingqing1,2, XIONG Zhuang1, HE Yong1, YANG Tao1, LU Ping1, WEI Xue1, XUE Wei1*. Synthesis and Biological Activity of Anthranilic Diamides Compounds Containing Methoxy and Benzothiazole [J]. Chinese Journal of Applied Chemistry, 2012, 29(07): 762-768.
[6]	ZHANG Lan, HUANG Ziyang*. Fabrication and Bioactivity of Porous Hydroxyapatite Coating by Electrophoretic Deposition Using Different Porogens [J]. Chinese Journal of Applied Chemistry, 2012, 29(01): 46-51.
[7]	ZHENG Yuguo1,2, WEI Xue1, GUO Qingqing1, LU Ping1, WANG Zhenchao1, XUE Wei1*. Synthesis and Biological Activities of Novel Bistriazolyl-3(2H)-pyridazinones [J]. Chinese Journal of Applied Chemistry, 2011, 28(09): 1028-1034.
[8]	ZHAO Jin1, XIE Huan-Xu2, LIU Hong-Yu2, MA Hong-Xia2, XIE Song-Qiang3, WANG Chao-Jie1*. Synthesis and Cytotoxicity of N,N-Bis(8-flavonmethyl)geranylamine Derivatives [J]. Chinese Journal of Applied Chemistry, 2010, 27(04): 398-403.
[9]	ZHENG Hui1, LIU Yun-Kui2, ZHAO Qing1, XU Zhen-Yuan2*. Synthesis and Biological Activity of Novel Fluorine-Containing Pyridine-Heterocyclic Carboxylate Compounds [J]. Chinese Journal of Applied Chemistry, 2010, 27(02): 164-168.
[10]	Huang Runqiu, Sun Jianyu, Ma Jun'an, Li Huiying. Synthesis and Bioactivity of Substituted Benzaldoxime Carboxylate─Ⅰ.Synthesis and Bioactivity of Substituted Benzaldoxime 3-(2,2-Dichloroethenyl)-2,2-dimethyl Cyclopropanecarboxylates [J]. Chinese Journal of Applied Chemistry, 1998, 0(1): 9-12.
[11]	Li Jinzhou, Yu Wenjin, Du Xiaoyan. Synthesis, Characterization and Bioactivity of Bis-Schiff Base Complexes of Furoylpyrazolone [J]. Chinese Journal of Applied Chemistry, 1997, 0(6): 98-100.
[12]	Si Zongxing, Du Xiaohua, Li Jingsong, Wang Xueming . Synthesis of Spin-labelling Auxins and Their Bioactivity [J]. Chinese Journal of Applied Chemistry, 1997, 0(4): 63-65.
[13]	Zhang Rong, Qian Xuhong. Synthesis and Bioactivity of 2,5-Disubstituted-1,3,4-Oxadiazoles and Their N,N'-Diacylhydrazine Precursors [J]. Chinese Journal of Applied Chemistry, 1996, 0(5): 5-9.
[14]	Sun Dayong, Liu Ziyang, Guo Xinghua, Liu Shuying. Preparation and Bioactivity of Water-Soluble C₆₀ Derivatives [J]. Chinese Journal of Applied Chemistry, 1996, 0(4): 1-4.
[15]	Shi Jingmin, Liao Daizheng, Cheng Peng, Miao Mingming, Jiang Zonghui, Liu Yongjiang, Wang Genglin. Synthesis、Magnetism and Cancer-Inhibiting Activity of μ-4-Nitrophthalato Binuclear Cobalt(Ⅱ) Complexes [J]. Chinese Journal of Applied Chemistry, 1996, 0(4): 86-88.