Synthesis and Biological Activities of N-(2-(Cyano(4,6-dimethoxypyrimidin-2-yl)methyl)phenyl) Substitued Amide Derivatives

doi:10.3724/SP.J.1095.2013.20541

Chinese Journal of Applied Chemistry

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Synthesis and Biological Activities of N-(2-(Cyano(4,6-dimethoxypyrimidin-2-yl)methyl)phenyl) Substitued Amide Derivatives

LI Yuanxiang^1,2*, CHEN Dizhao¹

(1.Chemistry and Chemical Engineering Department,Huaihua University,Huaihua 418008,China;
2.Key Laboratory of Pesticide & Chemical Biology,Education of Ministry,College of Chemistry,Central China Normal University,Wuhan 430079,China)

Received:2012-11-22 Revised:2012-12-29 Published:2013-09-10 Online:2013-09-10

Abstract

Abstract: Six novel N-(2-(cyano(4,6-dimethoxypyrimidin-2-yl)methyl)phenyl) substitued amide derivatives were synthesized using 2-(2-nitrophenyl)acetonitrile and 4,6-dimethoxy-2-(methylsulfonyl)pyrimidine as starting materials by condensation reaction, reduction reaction and acylation reaction, respectively. The structures of all synthesized compounds were determined by 1H NMR, MS and elemental analysis techniques. As-synthesized compounds did not show herbicidal activities at 150 g/hm2. The antibacterial activity test indicated that some of them exhibited certain inhibitory activities against Sphaerotheca fuliginea and Rhizoctonia solani, respectively at 200 mg/L. The inhibition rate of compound 4d against Rhizoctonia solani was 72.3% at 200 mg/L.

Key words: pyrimidinylsalicylic acid, dimethoxypyrimidine, Acidamide, synthesis, Bioactivity

CLC Number:

O621.2

LI Yuanxiang1,2*, CHEN Dizhao1. Synthesis and Biological Activities of N-(2-(Cyano(4,6-dimethoxypyrimidin-2-yl)methyl)phenyl) Substitued Amide Derivatives[J]. Chinese Journal of Applied Chemistry, DOI: 10.3724/SP.J.1095.2013.20541.

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Synthesis and Biological Activities of N-(2-(Cyano(4,6-dimethoxypyrimidin-2-yl)methyl)phenyl) Substitued Amide Derivatives

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