Abstract: An adsorptive voltammetric determination of neuroleptic drug haloperidol, is described.The drug adsorbed on the glassy carbon electrode gave an anodic stripping peak at about+0.73V(vs.Ag/AgCl) in Britton-Robinson buffer (pH = 9).The response is linear in con-centration range of 1×10^-9～1×10^-7 g/mL with a detection limit of 5×10^-10 g/mL after 10 minaccumulation.The scheme of open circuit preconcentration/medium exchange/stripping vol-tammetry is used to determine the drug in urine sample without preisolation.It is demons-trated that the adsorption of haloperidol on glassy carbon surface obeys Frumkin's isothermequation.

Key words: Haloperidol, chlorophenyl p-hydroxy piperidinyl fluorobutyrophenone, adsorption, stripping voltammetry