SYNTHESIS OF 4-(N-SUBSTITUTED)AMINOMETHYL PHENYLALANINES

Chinese Journal of Applied Chemistry ›› 1990, Vol. 0 ›› Issue (4): 72-74.

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SYNTHESIS OF 4-(N-SUBSTITUTED)AMINOMETHYL PHENYLALANINES

Liu Keliang¹, He Binglin¹, Xiao Shaobo²

1. Institute of Polymer Chemistry, Nankai University, Tianjin 300071;
2. Tianjin Municipal Research Institute for Family Palanning, Tianjin Medical College

Received:1989-08-21 Revised:1990-01-12 Published:1990-08-10 Online:1990-08-10

Abstract

Abstract: The new 4-(-N-substituted) aminomethyl phenylalanines are presented. Dialkylamine rea-cted with N-acetyl-4-chloromethyl phenylalanine ethyl ester to give phenylalanine derivativeswith basic side groups.After hydrolysis in hydrochloric acid and protection with Boc groupthe amino acids have been successfully used in solid phase peptide synthesis. This seriesamino acids combine basicity, aromaticity and hydrophilicity in the same molecule andhave different N-dialkyl groups in length, they can be used in systematic research onstructure-bioactivity relationships of peptides.

Key words: 4-(N-dialkyl)aminomethyl phenylanaline, nopnrotein amino acid, peptide

Liu Keliang, He Binglin, Xiao Shaobo. SYNTHESIS OF 4-(N-SUBSTITUTED)AMINOMETHYL PHENYLALANINES[J]. Chinese Journal of Applied Chemistry, 1990, 0(4): 72-74.

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SYNTHESIS OF 4-(N-SUBSTITUTED)AMINOMETHYL PHENYLALANINES

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