Research Progress of Nano-Gene Carriers Based on Liposomes

doi:10.11944/j.issn.1000-0518.2018.07.180031

Chinese Journal of Applied Chemistry ›› 2018, Vol. 35 ›› Issue (7): 735-744.DOI: 10.11944/j.issn.1000-0518.2018.07.180031

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Research Progress of Nano-Gene Carriers Based on Liposomes

Xu HAN^a,Guanyu DING^a,Qing DONG^a,Xiuyun YANG^a^*(),Dan LI^b^*(),Yan DU^b^*(),Erkang WANG^b^*()

^aSchool of Chemistry and Environmental Engineering,Changchun University of Science and Technology,Changchun 130022,China
^bState Key Laboratory of Electroanalytical Chemistry,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun 130022,China

Received:2018-01-30 Accepted:2018-05-03 Published:2018-07-06 Online:2018-07-06
Contact: Xiuyun YANG,Dan LI,Yan DU,Erkang WANG

Abstract

Abstract:

Gene therapy is a method for curing diseases caused by genetic defects and anomalies through introducing normal foreign genes into targeted cells. Efficient and sustained expression of foreign genes in cells is the decisive factor in gene therapy, which is significantly relied on the vectors used in the treatment. With the development of science and technology, the research of liposome/nanocomposites as gene carriers has widely attracted people's attention, due to the following advantages:versatile functions, easy surface modification, good biocompatibility, high transfection efficiency. Herein, the structure of liposome bilayer was introduced and the complexes of magnetic nanoparticles, gold nanoparticles, quantum dots, chitosan, upconversion nanoparticles with liposomes as gene carriers have been reviewed and prospected.

Key words: liposome, gene carrier, nanomaterials

Xu HAN, Guanyu DING, Qing DONG, Xiuyun YANG, Dan LI, Yan DU, Erkang WANG. Research Progress of Nano-Gene Carriers Based on Liposomes[J]. Chinese Journal of Applied Chemistry, 2018, 35(7): 735-744.

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Research Progress of Nano-Gene Carriers Based on Liposomes

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