Application of Cisplatin-loaded Thermosensitive Hydrogel in Local Chemotherapy of Cervical Cancer in Mice

doi:10.11944/j.issn.1000-0518.2017.10.170049

Chinese Journal of Applied Chemistry ›› 2017, Vol. 34 ›› Issue (10): 1127-1133.DOI: 10.11944/j.issn.1000-0518.2017.10.170049

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Application of Cisplatin-loaded Thermosensitive Hydrogel in Local Chemotherapy of Cervical Cancer in Mice

WANG Tong^a^c,LIU Shi^b^*(),ZHANG Xiuying^a^*()

^aVeterinary Pharmacology and Toxicology Laboratory,College of Veterinary Medicine,Northeast Agricultural University,Harbin 150030,China
^bState Key Laboratory of Polymer Physics and Chemistry,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun 130022,China
^cDaCheng Farm(Liaoning) Limited Company,Shenyang 110000,China

Received:2017-02-28 Accepted:2017-05-02 Published:2017-09-29 Online:2017-09-29
Contact: LIU Shi,ZHANG Xiuying
Supported by:
Supported by the National Natural Science Foundation of China(No.81602715)

Abstract

Abstract:

To explore the application of cisplatin-loaded thermosensitive hydrogel in the treatment of the cervical cancer in mice, cisplatin-loaded poloxamer thermosensitive hydrogel was prepared and characterized. The mouse uterine cervical cancer cell line U14 was injected into submucosa nearby the cervix in female mice. Drug-loaded hydrogel was infused into the vagina of tumor-bearing mice and the inhibitory effect was evaluated. The results show that the tumor inhibition rate is as high as 63.1% by vaginal administration of cisplatin-loaded poloxamer hydrogel, which presents a new formulation for the local drug delivery via vagina against cervical cancer.

Key words: cisplatin, thermosensitive hydrogel, cervical cancer, poloxamer

WANG Tong, LIU Shi, ZHANG Xiuying. Application of Cisplatin-loaded Thermosensitive Hydrogel in Local Chemotherapy of Cervical Cancer in Mice[J]. Chinese Journal of Applied Chemistry, 2017, 34(10): 1127-1133.

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Application of Cisplatin-loaded Thermosensitive Hydrogel in Local Chemotherapy of Cervical Cancer in Mice

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