Chinese Journal of Applied Chemistry ›› 2017, Vol. 34 ›› Issue (10): 1127-1133.DOI: 10.11944/j.issn.1000-0518.2017.10.170049

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Application of Cisplatin-loaded Thermosensitive Hydrogel in Local Chemotherapy of Cervical Cancer in Mice

WANG Tongac,LIU Shib*(),ZHANG Xiuyinga*()   

  1. aVeterinary Pharmacology and Toxicology Laboratory,College of Veterinary Medicine,Northeast Agricultural University,Harbin 150030,China
    bState Key Laboratory of Polymer Physics and Chemistry,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun 130022,China
    cDaCheng Farm(Liaoning) Limited Company,Shenyang 110000,China
  • Received:2017-02-28 Accepted:2017-05-02 Online:2017-09-29 Published:2017-09-29
  • Contact: LIU Shi,ZHANG Xiuying
  • Supported by:
    Supported by the National Natural Science Foundation of China(No.81602715)

Abstract:

To explore the application of cisplatin-loaded thermosensitive hydrogel in the treatment of the cervical cancer in mice, cisplatin-loaded poloxamer thermosensitive hydrogel was prepared and characterized. The mouse uterine cervical cancer cell line U14 was injected into submucosa nearby the cervix in female mice. Drug-loaded hydrogel was infused into the vagina of tumor-bearing mice and the inhibitory effect was evaluated. The results show that the tumor inhibition rate is as high as 63.1% by vaginal administration of cisplatin-loaded poloxamer hydrogel, which presents a new formulation for the local drug delivery via vagina against cervical cancer.

Key words: cisplatin, thermosensitive hydrogel, cervical cancer, poloxamer