Chinese Journal of Applied Chemistry

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Improved Suvival Quality of Mice with Cervical Cancer Through the Therapy of Sodium Dichloroacetate-loaded Electrospun Mats

LIU Daxing1,2, WANG Mingzhe1, JING Xiabin1, HUANG Yubin1*   

  1. (1.Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun 130022,China;
    2.University of Chinese Academy of Sciences,Beijing 100049,China)
  • Received:2013-10-31 Revised:2013-12-06 Published:2014-07-10 Online:2014-07-10

Abstract: Solidum dichloroacetate(DCA) loaded electrospun mats was fabricated through the solution electrospun method. When applying this DCA-loaded electrospun mats on the therapy of the subcutaneous cervical cancer model, a 94% tumor suppression rate and an overall 38% recovery rate were achieved after 19 days' treatment. The trend of recurrence and metastasis was also significantly inhabited. Meanwhile, DCA-loaded electropsun mats improved the life quality of tumor-bearing mice fundamentally. Therefore, DCA administrated by electrospun mats is a safe approach for the treatment of anti-cervical cancer.

Key words: cervical cancer, sodium dichloroacetate, electropsun mats, suvivial quality

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