Abstract: Cationic polyvinylpyrrolidone(CPVP) was synthesized by copolymerization of diallyldimethyl ammonium chloride(DADMAC) and vinylpyrrolidone(VP). Polydiallyldimethyl ammonium chloride(PDADMAC) and polyvinylpyrrolidone(PVP) were also synthesized. Their viscosity-average relative molecular masses were measured by viscometry and their structures were characterized by Fourier transform infrared spectroscopy(FTIR). CPVP, PDADMAC and PVP were mixed with ribonucleic acid(RNA) in different ratios in order to measure their loading property. The results indicate that the composite nanoparticles formed by mixing CPVP and RNA with a mass ratio of 2∶1 are about 300 nm with a polydistribution index of 0.0966 and the size distribution of nanoparticles is narrower than those of PVP and PDADMAC.

Key words: cationic, polyvinylpyrrolidone, ribonucleic acid, nanoparticle