Synthesis and Antitumor Activity of Oxime Ether Thiadiazolylthioethers

doi:10.3724/SP.J.1095.2013.20259

Chinese Journal of Applied Chemistry

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Synthesis and Antitumor Activity of Oxime Ether Thiadiazolylthioethers

ZHANG Yaozhou^1*, XIAO Ying¹, YANG Junjie¹, HU Guoqiang²

(1.Department of Biotechnology,Xinyang Agricultural College,Xinyang 464000,China；
2.Institute of Chemistry & Biology,Henan University,Kaifeng 475001,China)

Received:2012-06-11 Revised:2012-08-11 Published:2013-04-10 Online:2013-04-10

Abstract

Abstract: The synthesis of six oxime ether thiadiazolylthioether compounds(4a~4f) involved a β-chloropropiophenone substitution on 2-mercapto-5-substituded-1,3,4-thiadiazole, oximation with hydroxylamine and etherification with 5-chloromethyl-2-phenyl-1,3,4-oxadiazole. Their structures were characterized by 1H NMR, IR, MS and elemental analysis. The in vitro antitumor activities of the six compounds to B16, HL60 and SMMC-7721 cancer cell strains were evaluated by MTT assay. The preliminary results showed that some of them showed potential antiproliferation activity.

Key words: thiadiazole, oxadiazole, oxime ether, antitumor activity

CLC Number:

O626.2

ZHANG Yaozhou1*, XIAO Ying1, YANG Junjie1, HU Guoqiang2. Synthesis and Antitumor Activity of Oxime Ether Thiadiazolylthioethers[J]. Chinese Journal of Applied Chemistry, DOI: 10.3724/SP.J.1095.2013.20259.

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Synthesis and Antitumor Activity of Oxime Ether Thiadiazolylthioethers

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