Abstract: Ten title compounds have been prepared by reacting equal mole of 3-aryl-4-amino-5-mercapto-1,2,4-triazoles and aryl carboxylic acids in the presence of phosphorus oxychloride at 98 ℃ for 4～6 h. The structures of the compounds have been characterized by elemental analysis, IR, ¹H NMR and MS measurements. All the compounds were preliminary screened for antimicrobial activity against Staphylococcus aureus and Escherichia coli in 0.002% concentration. Some of the compounds exhibited a rather strong biological activity.

Key words: diaryl-triazolo[3,4-b]-thiadiazole, synthesis, biological activity