Abstract: In a planetary or a shaking ball milling machine, when H2O(50 μL) or DMF(50 μL) or methanol(150 μL) were added as assisting liquids in ball milling processes, the mechanochemical reactions between nicotinic acid and zinc oxide or basic zinc carbonate have been studied. The results show that ball milling the starting materials in the presence of H2O or DMF in the planetary(at 45 Hz) or shaking(at 20 Hz) ball milling machine, a zero-dimensional coordination compound, [Zn(NA)2(H2O)4] could be obtained after 30 min reactions. With the absence of DMF and methanol, the target compound could not be synthesized in a planetary ball milling process at lower frequency of 15 Hz. However, the similar reaction could be initiated once prolonging the reaction time to 60 min under similar conditions.