Synthesis and Antitumor Activity in Vitro of 5-Fluorouracil-1-alkylaxgphenyl-tetra m-Chlorophenyl Porphyrin Compounds

doi:10.3724/SP.J.1095.2012.20012

Chinese Journal of Applied Chemistry

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Synthesis and Antitumor Activity in Vitro of 5-Fluorouracil-1-alkylaxgphenyl-tetra m-Chlorophenyl Porphyrin Compounds

LI Ya^1*, SHEN Lihong¹, WANG Jiansen¹, HAN Shitian²

(1.Department of Chemistry,Handan College,Handan 056005,China;
2.College of Chemistry & Material Science,Hebei Normal University,Shijiazhuang 050016,China)

Received:2012-01-10 Revised:2012-04-06 Published:2013-01-10 Online:2013-01-10

Abstract

Abstract: To search for more potential antitumor agents, five new porphyrin-5-fluorouracil compounds were designed and synthesized. The reaction conditions were optimized and the separation method of the target products was explored. The compositions and structures of these compounds were confirmed by IR, UV-Vis, 1H NMR and MS. Their cytotoxicity against five human cancer cell lines in vitro was evaluated by MTT assay. Biological screening results demonstrate that some tested compounds exhibit potential antitumor activity, particularly, compound D3 shows more potential cytotoxic activities than the control 5-fluorouracil against Sk-ov-3 cells.

Key words: porphyrin, Fluorouraci, synthesis, antitumor activity in vitro

CLC Number:

O626

LI Ya1*, SHEN Lihong1, WANG Jiansen1, HAN Shitian2. Synthesis and Antitumor Activity in Vitro of 5-Fluorouracil-1-alkylaxgphenyl-tetra m-Chlorophenyl Porphyrin Compounds[J]. Chinese Journal of Applied Chemistry, DOI: 10.3724/SP.J.1095.2012.20012.

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Synthesis and Antitumor Activity in Vitro of 5-Fluorouracil-1-alkylaxgphenyl-tetra m-Chlorophenyl Porphyrin Compounds

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