Abstract: A series of O6-substituted purine derivatives was designed and prepared through an efficient and convenient method with 4-amino-pyridine as the catalyst in methanol solvent. Under optimized conditions:n(6-chloropurine)∶n(4-amino-pyridine)∶n(triethylamine)=10∶1∶4, refluxing for 5~7 h, the yield of 6-alkoxy purine was greater than 85%. Studies showed that, the relative amount of 6-chloropurine, 4-amino-pyridine and triethylamine in the system had a great influence on the reaction, and the highest catalytic activity was achieved using a mixture of 4-amino-pyridine and triethylamine as the catalyst.

Key words: amino-pyridines, Purine, catalyst, Oxyalkylation, synthesis