Chinese Journal of Applied Chemistry ›› 2010, Vol. 27 ›› Issue (09): 1105-1107.DOI: 10.3724/SP.J.1095.2010.90797

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Synthesis of Novel Pyridyl-pyrazole-5-carboxylic Acid Amide Compounds

ZHENG Yi, WANG Jun-Fang, ZHANG Ying-Peng*, YANG Yun-Shang   

  1. (School of Petrochemical Engineering,Lanzhou University of Technology,Lanzhou 730050)
  • Received:2009-11-30 Revised:2010-01-20 Published:2010-09-10 Online:2010-09-10

Abstract:

Key intermediate pyridinyl-1H-pyrazole-5-carboxylic acid was synthesized from the reaction of 2,3-dichloropyridine with hydrazine, which was then treated with diethyl maleate, then esterified through halogenation, oxidation, hydrolysis. Carbonyl chloride was synthesized by dichloro sulfoxide, and pyridinyl-1H-pyrazole-5-carboxylic acid amide compounds were synthesized by carbonyl chloride reacting with corresponding ammonia.

Key words: pyridyl-pyrazolecarboxylic acid, amide, synthesis

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