Synergistic Antibacterial Activity of Tetracycline Combined with Silver Nanoparticles

doi:10.19894/j.issn.1000-0518.210006

Chinese Journal of Applied Chemistry ›› 2021, Vol. 38 ›› Issue (11): 1462-1468.DOI: 10.19894/j.issn.1000-0518.210006

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Synergistic Antibacterial Activity of Tetracycline Combined with Silver Nanoparticles

GUO Shao-Bo, LIANG Yan-Li, LIU Zhi-Feng, ZHANG Qiang, MA Jian-Qi^*

School of Chemistry and Environmental Science, Shaanxi University of Technology, Hanzhong 723000,China

Received:2021-01-05 Accepted:2021-05-25 Published:2021-11-01 Online:2022-01-01
Supported by:
Science and Technology Project of Shaanxi Provincial Department of Education (No.20JK0571), the Key Laboratory of Catalytic Foundation and Application of Shaanxi Provincial (No.SLGPT2019KF01-20) and the Talent Starting Project of Shaanxi University of Technology (No.SLGRCQD2027)

Abstract

Abstract: Ag nanoparticles were successfully prepared from CF₃COOAg in the presence of NaSH, HCl and polyvinylpyrrolidone in diethylene glycol solvent. The nanoparticles were characterized by transmission electron microscopy (TEM), X-ray diffraction (XRD), ultraviolet-visible diffuse reflectance spectra (UV-Vis DRS), and X-ray photoelectron spectrometry (XPS). The combined antibacterial activities of Ag nanoparticles (NPs) and commercially available tetracycline against Escherichia coli (E.coli) and Staphylococcus aureus (S.aureus) by the disc diffusion assay and the colony count were evaluated. Strong synergistic antimicrobial effect of Ag NPs and tetracycline has been observed. The antimicrobial activity of tetracycline is improved by 31.3% and 24.5% to E.coli and S.aureus, respectively, in the presence of 50 μg/mL of Ag NPs, and is more sensitive to E.coli. The reason could be mainly ascribed to the presence of more proteins in the cell wall of E.coli than that of S.aureus. The results of this study demonstrate potential therapeutic applications of tetracycline in combination with Ag NPs.

Key words: Synergy, Bacteriostasis, Silver, Bacteriostasis mechanism, Coordination

CLC Number:

O614.1

GUO Shao-Bo, LIANG Yan-Li, LIU Zhi-Feng, ZHANG Qiang, MA Jian-Qi. Synergistic Antibacterial Activity of Tetracycline Combined with Silver Nanoparticles[J]. Chinese Journal of Applied Chemistry, 2021, 38(11): 1462-1468.

References

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Synergistic Antibacterial Activity of Tetracycline Combined with Silver Nanoparticles

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