Synthesis,Structure and Antitumour Activity of Cyclohexyl((trimethylsilyl)methyl)stannanediyl Bisarylcarboxylates

doi:10.11944/j.issn.1000-0518.2015.10.150059

Chinese Journal of Applied Chemistry ›› 2015, Vol. 32 ›› Issue (10): 1114-1119.DOI: 10.11944/j.issn.1000-0518.2015.10.150059

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Synthesis,Structure and Antitumour Activity of Cyclohexyl((trimethylsilyl)methyl)stannanediyl Bisarylcarboxylates

LIN Sen(),WU Yadi,DENG Ruihong,CAO Qianyong

Department of Chemistry,Nanchang University,Nanchang 330031,China

Received:2015-02-06 Accepted:2015-06-17 Published:2015-10-10 Online:2015-10-10
Contact: LIN Sen
Supported by:
Supported by the National Natural Science Foundation of China(No.21162017)

Abstract

Abstract:

Eight cyclohexyl((trimethylsilyl)methyl)stannanediyl bisarylcarboxylates were synthesized by the reaction of cyclohexyl(trimethylsilylmethyl)tin dichloride with arylcarboxylic acids. These compounds were characterized by IR, ¹H NMR and ¹³C NMR spectra and elemental analysis. The preliminary bioassay tests of these compounds show good antitumour activities in vitro against tumour cells A549 and the inhibition rates are over 75%.

Key words: diorganotin, synthesis, structure, antitumour activity

LIN Sen,WU Yadi,DENG Ruihong,CAO Qianyong. Synthesis,Structure and Antitumour Activity of Cyclohexyl((trimethylsilyl)methyl)stannanediyl Bisarylcarboxylates[J]. Chinese Journal of Applied Chemistry, 2015, 32(10): 1114-1119.

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Synthesis,Structure and Antitumour Activity of Cyclohexyl((trimethylsilyl)methyl)stannanediyl Bisarylcarboxylates

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