Synthesis, Structure and Properties of Tricyclohexyltin L-Mandeliate

doi:10.11944/j.issn.1000-0518.2015.10.150055

Chinese Journal of Applied Chemistry ›› 2015, Vol. 32 ›› Issue (10): 1120-1126.DOI: 10.11944/j.issn.1000-0518.2015.10.150055

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Synthesis, Structure and Properties of Tricyclohexyltin L-Mandeliate

ZHANG Fuxing(),KUANG Daizhi,FENG Yonglan,WANG Jianqiu,YU Jiangxi,JIANG Wujiu,ZHU Xiaoming

Department of Chemistry and Material Science,Hengyang Normal University,Key Laboratory of Functional Organometallic Materials of Hengyang Normal University,College of Hu'nan Province,Hengyang,Hu'nan 421008,China

Received:2015-02-05 Accepted:2015-07-13 Published:2015-10-10 Online:2015-10-10
Contact: ZHANG Fuxing
Supported by:
Supported by Hu'nan Province University Innovation Platform of Open Fund Project(No.12K124), Hu'nan Provincial Natural Science Foundantion of China(No.11JJ3021), Supported by Hu'nan Province University Science & Technology Innovation Team, Hu'nan Provincial Key Laboratory Foundantion of China

Abstract

Abstract:

Tricyclohexyltin L-mandeliate was synthesized by the reaction of tricyclohexyltin hydroxide with L-mandelic acid. Its structure has been determined by X-ray single crystal diffraction. The crystal is orthorhombic with space group P2₁2₁2₁, a=0.80825(4) nm, b=1.77151(8) nm, c=1.8385(2) nm, α=β=γ=90°, V=2.6324(2) nm³, Z=4, D_c=1.310 g/nm³, μ(MoKα)=9.92 cm^-1, F(000)=1080, R₁=0.0472, wR₂=0.1341. The tin atom has a distorted tetrahedral geometry. The stability of tricyclohexyltin L-mandeliate, its orbital energies and composition characteristics of some frontier molecular orbitals have been investigated by quantum chemistry calculation by means of G03W package and taking Lanl2dz basis set. Further more, thermal stability, electrochemical property, CD spectrum and anticancer activity of tricyclohexyltin L-mandeliate were also tested.

Key words: tricyclohexyltin L-mandeliate, synthesis, structure, antitumor activity

ZHANG Fuxing,KUANG Daizhi,FENG Yonglan,WANG Jianqiu,YU Jiangxi,JIANG Wujiu,ZHU Xiaoming. Synthesis, Structure and Properties of Tricyclohexyltin L-Mandeliate[J]. Chinese Journal of Applied Chemistry, 2015, 32(10): 1120-1126.

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Synthesis, Structure and Properties of Tricyclohexyltin L-Mandeliate

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