Removal of the Main Impurity from Benzafibrate by a Precipitation Method with Carbon Dioxide

doi:10.11944/j.issn.1000-0518.2015.09.150004

Chinese Journal of Applied Chemistry ›› 2015, Vol. 32 ›› Issue (9): 1088-1092.DOI: 10.11944/j.issn.1000-0518.2015.09.150004

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Removal of the Main Impurity from Benzafibrate by a Precipitation Method with Carbon Dioxide

WU Jie^a^*(),ZHANG Haijiang^a,YANG Guojun^b,WU Xiaochao^a

^aDepartment of Life Science and Chemical Engineering,Huaiyin Institute of Technology
^bJiangsu Tasly Diyi Pharmaceutical Co. Ltd.,Huaian,Jiangsu 223003,China

Received:2015-01-06 Accepted:2015-06-05 Published:2015-08-31 Online:2015-08-31
Contact: WU Jie
Supported by:
Supported by the Program of University-industry Cooperation of Jiangsu Province(No.BY2013052) and Huaian City(No.HC201207)

Abstract

Abstract:

According to the acidicity difference between the main impurity and benzafibrate, carbon dioxide was introduced into the alkaline product solution to remove the impurity from benzafibrate in the post-treatment process. The yield and content of the treated products were determined to compare the separation effect with different methods of precipitation and recrystallization. Compared with recrystallization, the yield of the product treated with CO₂ was increased from 62.5% to 70.9%. The method not only reduced the relatively large solvent consumption and product loss caused by the repeated recrystallization, but also effectively improved the removal rate of impurities and decreased the separation cost.

Key words: benzafibrate, carbon dioxide, precipitation, impurity

WU Jie,ZHANG Haijiang,YANG Guojun,WU Xiaochao. Removal of the Main Impurity from Benzafibrate by a Precipitation Method with Carbon Dioxide[J]. Chinese Journal of Applied Chemistry, 2015, 32(9): 1088-1092.

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Removal of the Main Impurity from Benzafibrate by a Precipitation Method with Carbon Dioxide

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