应用化学 ›› 2022, Vol. 39 ›› Issue (8): 1224-1236.DOI: 10.19894/j.issn.1000-0518.210500

• 研究论文 • 上一篇    下一篇

水性聚硅氧烷和聚乙烯醇复合物制备及其作为皮肤屏障材料的性能

陈炳刚1,3, 刘三荣1, 蒋子江2(), 于喜飞1,3()   

  1. 1.中国科学院长春应用化学研究所,高分子复合材料工程实验室,长春 130022
    2.中国科学院长春应用化学研究所,国家电化学和光谱研究分析中心,长春 130022
    3.中国科学技术大学,合肥 230026
  • 收稿日期:2021-10-15 接受日期:2022-01-20 出版日期:2022-08-01 发布日期:2022-08-04
  • 通讯作者: 于喜飞
  • 作者简介:zjjiang@ciac. ac. cn
  • 基金资助:
    国家自然科学基金项目(21674109)

Preparation and Properties Characterization of Hydrophilic Polysiloxane and Polyvinyl Alcohol Composite as Skin Barrier Material

Bing-Gang CHEN1,3, San-Rong LIU1, Zi-Jiang JIANG2(), Xi-Fei YU1,3()   

  1. 1.Laboratory of Polymer Composites Engineering,Changchun Institute of Applied Chemistry,Chinese Academy of Science,Changchun 130022,China
    2.National Analytical Research Center of Electrochemistry and Spectroscopy,Changchun Institute of Applied Chemistry,Chinese Academy of Science,Changchun 130022,China
    3.University of Science and Technology of China,Hefei 230026,China
  • Received:2021-10-15 Accepted:2022-01-20 Published:2022-08-01 Online:2022-08-04
  • Contact: Xi-Fei YU
  • About author:xfyu@ciac.ac.cn
  • Supported by:
    the National Natural Science Foundation of China Project(21674109)

摘要:

皮肤作为人体最外层的器官,容易遭受损伤,构建能够为皮肤提供保护作用的屏障材料具有非常重要的意义。基于皮肤屏障材料性能要求,将亲水改性的聚硅氧烷(PSI)和聚乙烯醇(PVA)相结合,通过原位Ca2+离子交联构建了一种复合多功能的皮肤屏障材料PSI-PVA。研究表明,该材料具有较好的干态和湿态力学性能,以及较好的皮肤相容性、可清洗性、亲水性、透气性、可修饰性和生物相容性。当PVA质量分数为20%时,溶胀率可达149%;随着PVA用量的增加,材料的清洗容易程度提高;紫外吸收剂羟基苯甲酮修饰后,材料的紫外光(200~400 nm)透过率在20%以下,在材料的保护下,小鼠胚胎成纤维细胞(NIH 3T3)在UVB(311 nm)照射后具有较高的存活率(71%)。因此,PSI-PVA可以满足皮肤屏障材料多项性能需求,在皮肤保护和受损修复等领域具有较好的应用前景。

关键词: 聚硅氧烷, 亲水改性, 聚乙烯醇, 离子交联, 皮肤屏障材料

Abstract:

As the outermost organ of human body, skin is easily injured. Therefore, it is more important to construct protected barrier material for skin. Herein, based on the performance requirement of skin barrier material, we construct a multifunctional skin barrier material PSI-PVA by combining hydrophilically modified polysiloxane (PSI) and polyvinyl alcohol (PVA) through ionic crosslinking. The test results indicate that PSI-PVA exhibits good stretchability in dry and wet and has compatible mechanical properties like skin. PSI-PVA is hydrophilic and the swelling ratio is up to 149% with the PVA content of 20%, and water can volatilize rapidly at room temperature, which makes PSI-PVA good breathability. PSI-PVA has good cleaning performance and can be easily cleaned from skin with water. In addition, PSI-PVA covalently linked with UV-absorbing group of hydroxybenzophenone can effectively decrease UV transmittance. The in vitro experiment indicates that NIH 3T3 cells have high survival rate (71%) irradiated by UVB (311 nm) with the protection of the PSI-PVA film. Furthermore, PSI-PVA also exhibits good biocompatibility through cell viability assay. The skin barrier material PSI-PVA constructed with composite of polysiloxane and polyvinyl alcohol can meet properties requirements and has good application prospects in fields of skin protection and injury repair.

Key words: Polysiloxane, Hydrophilic modification, Polyvinyl alcohol, Ionic crosslinking, Skin barrier material

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