聚对氨基苯磺酸/石墨烯电化学修饰电极检测药物中氧氟沙星

doi:10.11944/j.issn.1000-0518.2020.06.190332

摘要/Abstract

摘要：

基于石墨烯纳米材料和循环伏安法技术制备了聚对氨基苯磺酸/石墨烯修饰电极并研究了氧氟沙星(OFL)在该修饰电极上的电化学行为,建立了一种简单快速灵敏测定氧氟沙星的电化学分析方法。结果表明,与玻碳电极相比,对氨基苯磺酸/石墨烯电化学修饰电极能显著提高氧氟沙星的峰电流。在优化条件下,其检测线性范围为1~600 μmol/L,最低检测限为(S/N=3)0.33μmol/L。该修饰电极具有较好的重现性和稳定性,用于实际样品氧氟沙星滴眼液的测定,效果良好。

关键词: 石墨烯, 对氨基苯磺酸, 修饰电极, 氧氟沙星

Abstract:

A simple, rapid and sensitive electrochemical analysis method with a poly(p-aminobenzene sulfonic acid)/graphene modified glassy carbon electrode (pABSA/GR/GCE) for the determination of ofloxacin (OFL) is established based on GR nanomaterials and cyclic voltammetry (CV) in this study. Compared with the glassy carbon electrode, the peak current of OFL increases significantly using pABSA/GR/GCE. Under optimized experimental conditions, the pABSA/GR/GCE shows a good linear relationship with the concentration of OFL in the range of 1~600 μmol/L and a detection limit (S/N=3) of 0.33 μmol/L. The pABSA/GR/GCE is easy to be prepared with good reproducibility and stability. It has been used in the determination of ofloxacin eye drops with satisfactory results.

Key words: graphene, p-aminobenzene sulfonic acid, modified electrode, ofloxacin

司晓晶, 朱文菁, 李香, 李丽, 陈子超, 丁亚萍. 聚对氨基苯磺酸/石墨烯电化学修饰电极检测药物中氧氟沙星[J]. 应用化学, 2020, 37(6): 726-732.

SI Xiaojing, ZHU Wenjing, LI Xiang, LI Li, CHEN Zichao, DING Yaping. Determination of Ofloxacin in Medicine via Poly(p-aminobenzene sulfonic acid)/Graphene Electrochemical Modified Electrode[J]. Chinese Journal of Applied Chemistry, 2020, 37(6): 726-732.

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