4, 4', 6, 6'-四叔丁基-2, 2'-[乙二氧双(氮次甲基)]二酚铜(Ⅱ)化合物的合成、结构及抑菌活性

doi:10.11944/j.issn.1000-0518.2015.05.140287

摘要/Abstract

摘要：

在室温、无水乙醇溶剂中, H₂L(H₂L=4, 4', 6, 6'-四叔丁基-2, 2'-[乙二氧双(氮次甲基)]二酚)与一水合醋酸铜反应得到了一种新的铜(Ⅱ)化合物C₃₂H₄₆CuN₂O₄([CuL]), 并通过红外光谱、元素分析及X射线单晶衍射等技术手段对[CuL]进行了表征。 [CuL]的结构解析表明, 属单斜晶系, 空间群C2/c, 晶胞参数为a=2.7231(3) nm, b=1.1196(3) nm, c=1.0704(2) nm, α=90.00°, β=101.293(2)°, γ=90.00°, V=3.2002(11) nm³, Z=4, M_r=586.25, D_c=1.217 g/cm³, μ=0.718 mm^-1, F(000)=1252, R₁=0.0957, wR₂=0.2297。 [CuL]的对称单元中含有1个Cu(Ⅱ)原子和1个配位L分子组成, 中心Cu(Ⅱ)的配位数为4, 分别与来自L单元上的N1、N1#、O2、O2# 4个原子进行配位, 以金属离子为中心形成了稍微扭曲四面体结构的配位几何构型。对金黄色葡萄球菌、大肠杆菌和枯草杆菌的抑菌活性实验表明, [CuL]对3种菌均有显著的抑制作用, 其抑菌活性较配体L更强。

关键词: 铜(Ⅱ)化合物, 合成, 结构, 抑菌活性

Abstract:

A novel Cu(Ⅱ) compound, C₃₂H₄₆CuN₂O₄([CuL]), has been synthesized in ethanol by the reaction of H₂L(H₂L=4, 4', 6, 6'-tetra(tert-butyl)-2, 2'-[ethylenedioxybis(nitrilomethylidyne)]diphenol) with copper(Ⅱ) acetate monohydrate at room temperature and characterized by IR spectroscopy, elemental analyses and X-ray crystallography. The X-ray crystal structure of [CuL] crystallizes in a monoclinic system, space group C2/c, with a=2.7231(3) nm, b=1.1196(3) nm, c=1.0704(2) nm, α=90.00°, β=101.293(2)°, γ=90.00°, V=3.2002(11) nm³, Z=4, M_r=586.25, D_c=1.217 g/cm³, μ=0.718 mm^-1, F(000)=1252, R₁=0.0957, wR₂=0.2297. The symmetric unit in [CuL] contains one Cu(Ⅱ) atom and one coordinated L molecule. The central Cu(Ⅱ) atom are four-coordinated by N1, N1#, O2 and O2# atoms from the coordinated L unit. A slightly distorted tetrahedral geometry is formed around the central Cu(Ⅱ) atom. The antibacterial activities of H₂L and [CuL] are investigated using K-B method, the results indicate that [CuL] has remarkable antibacterial effect on Staphylococcus aureus, Escherichia coli and Withered grass bacillus. [CuL] has stronger activities against the three bacterias than the H₂L ligand.

Key words: Cu(Ⅱ) complex, synthesis, structure, antibacterial activity

中图分类号:

冯建华, 吴刚. 4, 4', 6, 6'-四叔丁基-2, 2'-[乙二氧双(氮次甲基)]二酚铜(Ⅱ)化合物的合成、结构及抑菌活性[J]. 应用化学, 2015, 32(5): 557-561.

FENG Jianhua, WU Gang. Synthesis, Structure and Antibacterial Activities of 4, 4', 6, 6'-Tetra(tert-butyl)-2, 2'-[ethylenedioxybis (nitrilomethylidyne)]diphenol and Its Cu(Ⅱ) Complex[J]. Chinese Journal of Applied Chemistry, 2015, 32(5): 557-561.

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