三唑酰胺1,4-戊二烯-3-酮衍生物的合成及生物活性

doi:10.11944/j.issn.1000-0518.2015.04.140251

摘要/Abstract

摘要：

以丙酮和水杨醛为起始原料,设计合成了9个新型含氟1,2,4-三唑酰胺姜黄素类化合物,通过¹H NMR、¹⁹F NMR、IR及元素分析等技术手段对目标化合物进行了结构表征。采用Airbrush喷雾法进行生物活性测试,结果表明部分化合物具有不同程度的杀虫活性。

关键词: 姜黄素, 三唑, 合成, 生物活性

Abstract:

Using acetone and 2-hydroxybenzaldehyde as starting materials, nine novel curcumin derivatives containing 1,2,4-triazole and amide units were synthesized. The structures were confirmed by ¹H NMR, ¹⁹F NMR, IR and elemental analysis. The preliminary result of bioassay by airbrush spraying shows that some of the compounds obtianed exhibit weak to moderate insecticidal activity.

Key words: curcumin derivatives, triazole, synthesis, biological activity

中图分类号:

O626.2

郑玉国, 邓钊, 宋松, 周彩, 罗明左, 宁艳, 郭晴晴. 三唑酰胺1,4-戊二烯-3-酮衍生物的合成及生物活性[J]. 应用化学, 2015, 32(4): 405-411.

ZHENG Yuguo , DENG Zhao, SONG Song, ZHOU Cai, LUO Mingzuo, NING Yan, GUO Qingqing. Synthesis and Biological Activity of Novel Triazoleamide-1,4-Pentadien-3-one Derivatives[J]. Chinese Journal of Applied Chemistry, 2015, 32(4): 405-411.

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