5-[(3-吲哚基)-甲基]-2,2-二甲基-1,3-二噁烷-4,6-二酮衍生物的高效合成

doi:10.11944/j.issn.1000-0518.2015.03.140197

摘要/Abstract

摘要：

在分子碘作用下,以吲哚、醛和2,2-二甲基-1,3-二噁烷-4,6-二酮为原料,通过三组分缩合反应合成了10种5-[(3-吲哚基)-甲基]-2,2-二甲基-1,3-二噁烷-4,6-二酮衍生物。当催化剂的用量为5%(摩尔分数)时,30 ℃反应60~90 min,收率为71.4%~97.3%。此外,还探讨了分子碘的催化机理。

关键词: 二甲基二噁烷二酮, 碘, 醛, 三组分反应

Abstract:

Ten 5-[(indol-3-yl)-methyl]-2,2-dimethyl-1,3-dioxane-4,6-dione derivatives were synthesized by the three component condensation reaction of indole, aldehyde and 2,2-dimethyl-1,3-dioxane-4,6-dione using iodine as the catalyst. The results indicates that the yields range from 71.4% to 97.3% at 30 ℃ for 60~90 min using 5% molar fraction of iodine. Furthermore, a mechanism for the reaction catalyzed by iodine is proposed.

Key words: dimethyl-dioxane-dione, iodine, aldehydes, three component condensation reaction

中图分类号:

许招会, 林春花, 廖维林. 5-[(3-吲哚基)-甲基]-2,2-二甲基-1,3-二噁烷-4,6-二酮衍生物的高效合成[J]. 应用化学, 2015, 32(3): 278-283.

XU Zhaohui, LIN Chunhua, LIAO Weilin. Efficient One-Pot Synthesis of 5-[(Indol-3-yl)-methyl]-2,2-dimethyl-1,3-dioxane-4,6-dione Derivatives[J]. Chinese Journal of Applied Chemistry, 2015, 32(3): 278-283.

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