Ugi反应在环肽生物碱和小肽衍生物抗生素及细胞毒素类等天然产物合成中的应用

doi:10.3724/SP.J.1095.2013.30002

摘要/Abstract

摘要： Ugi反应是由1分子醛或酮、1分子胺、1分子异腈和1分子羧酸4个组分通过缩聚反应生成α-酰氨基酰胺类化合物的反应。具有反应条件温和、产率高和原子经济性好等特点。该反应还可与Suzuki、Heck和Smiles等经典反应偶联，使得其在天然产物合成方面得到越来越多的关注。本文概括总结了近几十年来Ugi反应在一些天然产物合成中的应用。

关键词: Ugi反应, 天然产物, 合成

Abstract: Ugi reaction is an important multicomponent reaction to yield polycondensation α-amido amide in which a molecule of aldehyde or ketone, an amine, an isocyanide and a carboxylic acid were involved. The reaction not only possesses the advantages of mild reaction condition, high yield and atom economy, but also can couple with some classical chemical reactions, for example, Suzuki, Heck and Smiles. Therefore it has attracted more and more research interest in the synthesis of natural products. The article generally summarizes the application of Ugi reaction in the synthesis of natural products in recent decades.

Key words: Ugi reaction, natural products, synthesis

中图分类号:

O621.3

张峰, 方正, 李小林, 何伟, 袁爱邦, 郭凯. Ugi反应在环肽生物碱和小肽衍生物抗生素及细胞毒素类等天然产物合成中的应用[J]. 应用化学, DOI: 10.3724/SP.J.1095.2013.30002.

ZHANG Feng1, FANG Zheng1, LI Xiaolin1, HE Wei1, YUAN Aibang2, GUO Kai2*. Applications of Ugi Reaction to the Synthesis of Natural Products[J]. Chinese Journal of Applied Chemistry, DOI: 10.3724/SP.J.1095.2013.30002.

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