中华医学超声杂志

应用化学 ›› 1998, Vol. 0 ›› Issue (6): 45-48.

• 研究论文 • 上一篇    下一篇

β-环糊精对D/L-酪氨酸对映体的手性识别及超分子包合物的合成

张有明, 魏太保   

  1. 西北师范大学化学系 兰州730070
  • 收稿日期:1998-04-20 修回日期:1998-10-09 出版日期:1998-12-10 发布日期:1998-12-10
  • 基金资助:
    国家自然科学基金(29571023)

Chiral Recognition of D/L-Tyrosine by β-Cyclodextrin and Synthesis of Supramolecular Inclusion Compound

Zhang Youming, Wei Taibao   

  1. Department of Chemistry, Northwest Normal University, Lanzhou 730070
  • Received:1998-04-20 Revised:1998-10-09 Published:1998-12-10 Online:1998-12-10

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摘要： 利用圆二色谱研究了β-环糊精(β-CD)对D/L酪氨酸的手性识别行为,制备出了β-CD与L-酪氨酸(L-Tyr)的固体超分子化合物,并用元素分析、薄层分析、X射线粉末衍射及热分析对包合物进行了表征,用荧光光谱法测定了包合物的形成常数。实验结果表明,β-CD具有选择包结L-酪氨酸的特性；主客体形成1へ1的包合物,其组成为L-Tyr/β-CD·12H2O;稳定常数为5.13×103L/mol;包合物的热稳定性比主客体皆有改善.

关键词: 环糊精, 酪氨酸, 超分子包合物, 合成, 手性识别

Abstract: The chiral recognition action of β-cyclodextrin(CD) to D/L-tyrosine(D/L-tyr) have been studied by circular dichroism measurement. The solid supramolecular inclusion compound of β-CD with L-tyr has been prepared and characterized by elemental analysis, thermal analysis, thin-layer chromatography and X-ray diffraction analysis. The inclusion equilibrium constants were obtained approximately by fluorescence spectrophotometry. The results indicated that β-CD showed a higher affinity for L-tyr than for D-tyr and it formed a 1へ1 hostguest compound with Ltyr of constitution L-tyr/β-CD·12H2O. The formation constant is calculated to be 5.13×103 mol-1L. The inclusion compound had a more or less greater thermal stability than tyrosine and β-CD.

Key words: β-cyclodextrin, D/L-tyrosine, supramolecular inclusion compound, synthesis, chiral recognition

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