中华医学超声杂志

应用化学 ›› 1998, Vol. 0 ›› Issue (5): 39-42.

• 研究论文 • 上一篇    下一篇

Uniconazole-P的合成

廖联安, 崔厚祥, 陈明德, 张洪奎, 郭奇珍   

  1. 厦门大学化学系 厦门361005
  • 收稿日期:1997-11-28 修回日期:1998-06-30 出版日期:1998-10-10 发布日期:1998-10-10
  • 基金资助:
    南开大学国家元素有机化学重点实验室基金

Synthesis of Uniconazole-P

Liao Lianan, Cui Houxiang, Chen Mingde, Zhang Hongkui, Guo Qizhen   

  1. Department of Chemistry, Xiamen University, Xiamen 361005
  • Received:1997-11-28 Revised:1998-06-30 Published:1998-10-10 Online:1998-10-10

PDF

491

被引次数

1

摘要： 对氯苯甲醛与α-三唑基频哪酮在KF/Al2O3/PEG4000存在下经Knoevenagel反应得85%烯基三唑酮(Ⅱ)(E/Z=0.65),Ⅱ经光异构化得92%E-Ⅱ(E/Z≥99/1);E-Ⅱ在手性相转移催化剂的存在下进行选择性不对称还原得92%Uniconazole-P(Ⅰ),ee=30%,E/Z≥99/1.Ⅰ是高效的植物生长延缓剂。

关键词: Uniconazole-P, 合成, Knoevenagel反应, 不对称还原

Abstract: 4-Chlorophenyl acetaldelyde reacting with α-triazolylpinacolone in the presence of KF/Al2O3/PEG4000 will produce 85% vinyltriazolyl ketone(Ⅱ) with E/Z =0.65; Ⅱ is then isomerized by light to a yield of 92% E-Ⅱ with E/Z ≥99/1. It is then reduced in the presence of certain charge transfer catalyst V by KBH4 to 92% Uniconazole-P with ee of 30%.

Key words: Uniconazole-P, synthesis, Knoevenagel reaction, asymmetric reduction

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