中华医学超声杂志

应用化学 ›› 1998, Vol. 0 ›› Issue (3): 59-62.

• 研究论文 • 上一篇    下一篇

3-吡唑基-6-取代均三唑并[3,4-b]-1,3,4-噻二唑的合成及生物活性

陈寒松, 李正名   

  1. 南开大学元素有机化学研究所 天津300071
  • 收稿日期:1997-10-21 修回日期:1998-03-16 出版日期:1998-06-10 发布日期:1998-06-10

Synthesis and Biological Activities of 3-Pyrazolyl-6-substituted-s-triazolo[3,4-b]-1,3,4-thiadiazoles

Chen Hansong, Li Zhengming   

  1. Institute of Elemento Organic Chemistry, Nankai University, Tianjin 300071
  • Received:1997-10-21 Revised:1998-03-16 Published:1998-06-10 Online:1998-06-10

PDF

351

被引次数

54 | 11

摘要： 以1-甲基-3-乙基(-4-氯)-5-吡唑甲酰肼作原料,经两步得到4-氨基-3-(1'-甲基-3'-乙基(-4-氯)-5-吡唑基)-1,2,4-三唑-5-硫酮(3),3再与取代羧酸反应,得到一系列3-(1'-甲基-3'-乙基(-4'-氯)-5'-吡唑基)-6-取代均三唑并3,4-b]-1,3,4-噻二唑(4、5、6).元素分析、1H NMR、IR和MS确定了它们的结构。初步生测结果表明：3具有植物生长调节活性,4b、4d、6具有杀菌活性。

关键词: 吡唑, 均三唑并[3,4-b]-1,3,4-噻二唑, 合成, 生物活性

Abstract: In view of the biological activity of s-triazolo[3,4-b]-1,3,4-thiadiazole fused heterocyclic derivatives, nine novel compounds 3-((4'-chloro)-3'-ethyl-1'-methyl-5'-pyrazolyl)-6-substituted-s-triazolo[3,4-b]-1,3,4-thiadiazoles (4a～g,5,6) were synthesized by condensation of carboxylic acid with 4-amino-3-((4'-chloro)-3'-ethyl-1'-methyl-5'-pyrazolyl)-1,2,4-triazole-5-thione. Their structures were characterized by elemental analysis, 1H NMR , IR and MS spectroscopy. The preliminary bioassay tests showed that compound 3 exhibited plant growth regulation activity and 4b, 4d and 6 possessed moderate fungicidal activity .

Key words: pyrazolyl-s-triazolo[3,4-b]-1,3,4-thiadiazole, synthesis, bioassay

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