中华医学超声杂志

应用化学 ›› 1996, Vol. 0 ›› Issue (5): 14-16.

• 研究论文 • 上一篇    下一篇

2－硫代磷酸酯基－3,4－二氢呋喃并喹啉化合物的合成和抑菌活性

刘准, 李树正, 米中茂, 张春香, 孙莹   

  1. 南开大学元素有机化学研究所 天津 300071
  • 收稿日期:1995-11-23 修回日期:1996-05-17 出版日期:1996-10-10 发布日期:1996-10-10
  • 基金资助:
    国家自然科学基金

Synthesis and Bioactivity of Some 2-Thiophosphate-3,4-Dihydrofuroquinolines

Liu Zhun, Li Shuzheng, Mi Zhongmao, Zhang Chunxiang, Sun Ying   

  1. Institute of Elemento-Organic Chemistry, Nankai University, Tianjin 300071
  • Received:1995-11-23 Revised:1996-05-17 Published:1996-10-10 Online:1996-10-10

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摘要： 6-取代基-2-氧-3,4-二氢呋喃并喹啉类化合物用氢化钠还原所生成的醇钠与硫代磷酰氯缩合制备3,4-二氢呋喃并喹啉化合物,通过1H NMR,MS和元素分析鉴定了它们的结构,并初步测试了它们的抑菌活性。

关键词: 合成, 二氢呋喃并喹啉, 硫代磷酸酯, 抑菌活性

Abstract: Ten new title compounds were synthesized by condensation of thiophosphoryl chlorides and 2-sodium alcoholate-6-substitutent-3, 4-dihydrofuroquinolines, the latter being prepared from the reduction of corresponding 2-oxo compounds with sodium hydride. Their structures were confirmed by 1H NMR, MS, and elemental analysis. Some of them have good antifungous activity to pellicularia sasakii of rice.

Key words: synthesis, dihydrofuroquinoline, thiophosphate, antifungous activity

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