应用化学 ›› 1996, Vol. 0 ›› Issue (2): 15-17.

• 研究论文 • 上一篇    下一篇

联苯乙酮缩氨基硫脲合铜(Ⅱ)配合物的合成和生物活性

毕思玮1, 刘树祥1, 刘永军1, 孙海涛1, 田君廉1, 李桂芝2   

  1. 1. 曲阜师范大学化学系 曲阜 273165;
    2. 曲阜师范大学生物系 曲阜
  • 收稿日期:1995-09-20 修回日期:1995-12-20 出版日期:1996-04-10 发布日期:1996-04-10
  • 基金资助:
    山东省自然科学基金

Synthesis and Antibacterial Activity of Copper(Ⅱ) Acetylbiphenyl Thiosemicarbazone Complex

Bi Siwei1, Liu Shuxiang1, Liu Yongjun1, Sun Haitao1, Tian Junlian1, Li Guizhi2   

  1. 1. Department of Chemistry, Qufu Normal University, Qufu 273165;
    2. Department of biology, Qufu Normal University, Qufu
  • Received:1995-09-20 Revised:1995-12-20 Published:1996-04-10 Online:1996-04-10

摘要: 合成了联苯乙酮缩氨基硫脲及其与Cu(Ⅱ)的配合物,通过元素分析、摩尔电导、红外光谱和电子光谱等进行表征,证明配合物为四配位的平面正方形结构。用pH法测定了配体的质子化常数和配合物的稳定常数。抗菌活性实验表明,配体具有良好的抑菌活性,与Cu(Ⅱ)形成配合物后抑菌活性大大增强。

关键词: 席夫碱, 联苯乙酮缩氨基硫脲, 铜(Ⅱ), 抗菌活性, 稳定常数

Abstract: The new ligand 4-acetylbiphenyl thiosemicarbazone and its complex with Cu(Ⅱ) were synthesized and characterized by elemental analysis, molar conductance, infrared and electronic spectra.The stability constant of the complex was determined using pH method. The antibacterial activities of the ligand and the complex against S. aureus, S. flexneri 2b, B. subtilis, B. proteus and A. aerogenes were examined. Experimental results showed that both have high antibacterial activities and the complex is more active than the ligand.

Key words: schiff base, acetylbiphenyl thiosemicarbazone, Cu (Ⅱ), antibacterial activity, stability constant