中华医学超声杂志

应用化学 ›› 2010, Vol. 27 ›› Issue (05): 523-527.DOI: 10.3724/SP.J.1095.2010.90345

• 研究论文 • 上一篇    下一篇

5-[β-(2-羟苯基)丙炔酰胺基]-5-去氧腺苷的合成

洪珊珊,胡延维,乔春华*   

  1. (苏州大学医学部药学院 苏州 215123)
  • 收稿日期:2009-05-13 修回日期:2009-08-29 出版日期:2010-05-10 发布日期:2010-05-10
  • 通讯作者: 乔春华,女,教授; E-mail:qiaochunhua@suda.edu.cn; 研究方向：药物合成

Synthesis of the 5'-(2-hydroxylphenyl)-propynoylamide-5'-deoxy-aminoadenosine

HONG Shan-Shan, HU Yan-Wei, QIAO Chun-Hua*   

  1. (School of Pharmacy,Medical College of Soochow University,Suzhou 215123)
  • Received:2009-05-13 Revised:2009-08-29 Published:2010-05-10 Online:2010-05-10

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摘要：

为寻找新型的抗结核化合物，合成了核苷类化合物5-[β-(2-羟苯基)丙炔酰胺基]-5-去氧腺苷。 以邻碘苯酚为原料，经过Sonogashira、缩合等一系列反应合成了该新化合物，并优化了合成反应的条件。 其结构经过红外、核磁共振和高分辨质谱测试技术确证。

关键词: MbtA, MbtB, 抑制剂, 核苷类化合物, 合成

Abstract:

To develop a novel inhibitor of Mycobacterium tuberculosis, a new compound 5-[β-(2-hydroxylphenyl)propynoylamic]-5-deoxyadenosine was synthesized from the starting material of 2-iodine phenol via a series of reactions such as Sonogashira and condensation reactions. The experimental conditions were optimized. The structure of the compound was determined by 1H NMR, 13C NMR, IR and LC/MS.

Key words: MbtA, MbtB, inhibitor, nucleoside compounds, synthesis

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