中华医学超声杂志

应用化学 ›› 2010, Vol. 27 ›› Issue (02): 178-182.DOI: 10.3724/SP.J.1095.2010.90098

• 研究论文 • 上一篇    下一篇

硅钨酸与氧氟沙星的相互作用

高盐生1,周秋华2,张红梅2,王彦卿1*   

  1. (1.江苏盐城技师学院 盐城；2.盐城师范学院化学化工学院 盐城 224002)
  • 收稿日期:2009-02-16 修回日期:2009-05-11 出版日期:2010-02-10 发布日期:2010-02-10
  • 通讯作者: 王彦卿，男，硕士，讲师; E-mail:wyqing76@126.com; 研究方向：生物无机化学
  • 基金资助:
    江苏省高校自然科学基础研究项目(07KJD150235)，江苏省“青蓝工程”资助项目

Interaction between Silicotungstic Heteropolyacid and Ofloxacin

GAO Yan-Sheng1, ZHOU Qiu-Hua2, ZHANG Hong-Mei2, WANG Yan-Qing1*   

  1. (1.Yancheng Technician Institute,Yancheng;
    2.School of Chemistry and Chemical Engineering,Yancheng Teachers University,Yancheng 224002)
  • Received:2009-02-16 Revised:2009-05-11 Published:2010-02-10 Online:2010-02-10

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1135

被引次数

1

摘要：

利用荧光光谱及红外光谱法研究了硅钨杂多酸与氧氟沙星分子的相互作用。结果表明，在溶液中硅钨酸分子与氧氟沙星生成新的配合物，导致氧氟沙星溶液荧光的猝灭，其猝灭类型主要为静态猝灭。通过测定反应的表观结合常数、结合位点数及结合热力学参数，证明硅钨酸与氧氟沙星分子主要通过静电和疏水作用形成配合物, 配合物中的硅钨酸仍保持Keggin结构。

关键词: 硅钨酸, 氧氟沙星, 荧光光谱, 相互作用

Abstract:

A complex composed of ofloxacin(OFLX) and silicotungstic heteropolyacid (SiW) was studied by fluorescence and IR spectroscopy. SiW can quench the fluorescence of OFLX by forming a new complex. The binding site number n, apparent binding constant KA and corresponding thermodynamic parameters were measured at different temperatures. This indicates that the electrostatic and hydrophobic interactions play a major role in stabilizing the complex. The IR spectrum confirmed the presence of Keggin type anion in the SiW-OFLX complex.

Key words: silicotungstic heteropolyacid, ofloxacin, fluorescence spectroscopy, interaction

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