蛋白质微阵列芯片在临床分析中的应用

doi:10.11944/j.issn.1000-0518.2016.11.160315

摘要/Abstract

摘要：

蛋白质微阵列芯片能够高通量监测生物毒素、分析宿主-微生物相互作用和抗原-抗体相互作用、筛选疾病生物标志物,因此有望成为体外诊断的主要技术之一并在病原体感染、自身免疫性疾病、神经退行性疾病和癌症等疾病的精准医疗中发挥重要作用。本文通过对最近发表的相关研究成果分析,总结了蛋白质微阵列芯片在临床分析中新进展,分析了其在实际应用中所面临的技术挑战并探讨了相应的解决方案。

关键词: 蛋白质微阵列芯片, 临床检测, 高通量分析, 生物分子相互作用

Abstract:

Protein microarray is capable of high-throughput monitoring biological toxins, analyzing the host-microbe interactions and the antigen-antibody interaction, and screening biomarkers of diseases. Therefore, protein microarray is expected to become one of the main technology of in vitro diagnostic and plays an important role in precision medicine of many diseases, such as pathogen infection, autoimmune diseases, neurodegenerative diseases, cancer and so on. Through analyzing the recently published research results, this review summarizes recent progress of protein microarray in the clinical analysis, analyzes the technical challenges in practical application, and discusses corresponding solutions.

Key words: protein microarray, clinical detection, high-throughput analysis, biological molecular interaction

李铸衡,刘霞,刘殿骏,王振新. 蛋白质微阵列芯片在临床分析中的应用[J]. 应用化学, 2016, 33(11): 1253-1264.

LI Zhuheng,LIU Xia,LIU Dianjun,WANG Zhenxin. Application of Protein Microarray in Clinical Analsis[J]. Chinese Journal of Applied Chemistry, 2016, 33(11): 1253-1264.

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