阿司匹林铜(Ⅱ)配合物的合成、晶体结构和抗肿瘤活性

doi:10.3724/SP.J.1095.2014.30202

摘要/Abstract

摘要： 合成了阿司匹林铜(Ⅱ)配合物，通过红外、X射线单晶衍射对其结构进行了表征。配合物属单斜晶系，P21/n空间群，晶胞参数为a=8.211(5) nm，b=10.419(5) nm，c=21.003(5) nm，β=98.021(5)°，V=1779.2(14) nm3，Z=4。采用紫外光谱和荧光光谱法及循环伏安法研究了配合物与小牛胸腺DNA(ct-DNA)的相互作用。采用MTT法测定了配合物对体外培养人乳腺癌MCF-7和胃癌MGC-803细胞的抑制活性。当配合物浓度为120 μmol/L时，对2种细胞增殖的抑制率分别为80.01%和70.16%。

关键词: 阿司匹林铜(Ⅱ)配合物, 晶体结构, 抗肿瘤活性, ct-DNA, 相互作用

Abstract: A Cu(Ⅱ)-aspirin complex has been synthesized and characterized by IR spectroscopy and single crystal X-ray diffraction analyses. The complex crystallizes in monoclinic space group P21/n with cell parameters of a=8.211(5) nm， b=10.419(5) nm， c=21.003(5) nm， β=98.021(5)°， V=1779.2(14) nm3， Z=4. The interactions of the complex with ct-DNA were studied by UV, fluorescence spectroscopy and cyclic voltammetry method. At the same time, the antitumor activities of the complex against MCF-7 and MGC-803 cell lines were tested by MTT assay. The in vitro inhibitory ratios against two tumor cell lines are 80.01% and 70.16% at concentration of 120 μmol/L, respectively.

Key words: Cu(Ⅱ)-aspirin complex, crystal structure, antitumor activity, ct-DNA, interaction

中图分类号:

O614.1

刘涛, 魏冬, 姜波, 徐国永, 周双生. 阿司匹林铜(Ⅱ)配合物的合成、晶体结构和抗肿瘤活性[J]. 应用化学, DOI: 10.3724/SP.J.1095.2014.30202.

LIU Tao1, WEI Dong1, JIANG Bo1, XU Guoyong1, ZHOU Shuangsheng1,2*. Synthesis，Characterization and Antitumor Activitiesof of Cu(Ⅱ)-Aspirin Complex[J]. Chinese Journal of Applied Chemistry, DOI: 10.3724/SP.J.1095.2014.30202.

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