关键词: 苯基甲磺酰胺, 合成, 表征, 标记前体

Abstract: A new ligand N-[2-cyclohexylmethoxy-4(1-(2,2′-bipyridinemethyl)amino)acetylamino] phenylmethanesulfonamide(NSC-PA), for potential labeling [99mTc(CO)3(H2O)3]+ was synthesized by hydroxyl-alkylation, amino-methylsulfonylation, nitro-reduction, amino-bromideacetylation and N-alkylation from 2-amino-5-nitrophenol. Simple experimental operation, short period and purified products could be obtained under optimized conditions. The structures of all the compounds were confirmed by 1H NMR, IR and MS. The purity of the target compound was over 98% as given by HPLC result. The target product could be used for future labeling studies. This synthesis is promising in the exploration of new imaging reagent for breast cancer.

Key words: phenylmethanesulfonamide, synthesis, optimization, labeling ligand