应用化学 ›› 2010, Vol. 27 ›› Issue (03): 300-303.DOI: 10.3724/SP.J.1095.2010.90243

• 研究论文 • 上一篇    下一篇

4-去甲斑蝥酰亚胺基丁酰苯硫脲的合成及抗惊厥活性

魏初铨,李泳秀,孙晓飞*   

  1. (苏州大学医学部药学院 苏州 215123)
  • 收稿日期:2009-04-07 修回日期:2009-07-15 出版日期:2010-03-10 发布日期:2010-03-10
  • 通讯作者: 孙晓飞,男,教授; E-mail:sunxiaofei@suda.edu.cn; 研究方向:天然药物化学教学及新药开发

Synthesis of γ- Aminobutyric Acid Isothiocyanate Conjugated Norcantharidin and Substituted Anilin And Anticonvulsant Activity

WEI Chu-Quan, LI Yong-Xiu, SUN Xiao-Fei*   

  1. (School of Pharmacy,Medical College of Soochow University,Suzhou 215123)
  • Received:2009-04-07 Revised:2009-07-15 Published:2010-03-10 Online:2010-03-10

摘要:

合成了十一个γ-氨基丁酸异硫氰酯偶联去甲斑蝥素与取代苯胺目标化合物,其结构经IR、1H NMR和HR-MS测试技术确证。抗惊厥活性初步测定表明,化合物II2、II3和II8显示了较强的抗惊厥活性。

关键词: 去甲斑蝥素, 去甲斑蝥酰亚胺基丁酰苯硫脲, 抗惊厥, 合成

Abstract:

In order to find new anticonvulsant compounds, we designed and synthesized eleven target compounds of the γ- Aminobutyric acid isothiocyanate conjugated norcantharidin and substituted anilin. The structures are identified by IR, 1H NMR and HR-MS. Preliminary test of anticonvulsant activity showed that compounds II2, II3 and II8 had appreciable antiepileptic activity.

Key words: norcantharidin, γ- aminobutyric acid isothiocyanate conjugated norcantharidin and substituted anilin, anticonvulsant, synthesis

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