中华医学超声杂志

应用化学 ›› 2009, Vol. 26 ›› Issue (10): 1134-1138.

• 研究论文 • 上一篇    下一篇

微波辅助壳聚糖接枝聚乳酸共聚物的合成及表征

何柱国,罗丙红,周长忍,程松,张奕,钟翠红   

  1. (暨南大学理工学院材料科学与工程系，生物材料实验室，人工器官与材料教育部工程中心 广州 510632)
  • 收稿日期:2008-10-17 修回日期:2008-12-24 出版日期:2009-10-10 发布日期:2009-10-10
  • 通讯作者: 周长忍，男，博士，教授; E-mail:tcrz9@jnu.edu.cn; 研究方向：生物材料
  • 基金资助:
    国家自然科学基金(30500128)国家高技术研究发展计划(“八六三”计划)(2007AA091603)资助项目

Microwave-assisted synthesis and characterization of chitosan-graft-poly(D,L-lactide) copolymers

HE Zhu-Guo, LUO Bing-Hong, ZHOU Chang-Ren, CHENG Song, ZHANG Yi, ZHONG Cui-Hong   

  1. (Biomaterials Research Laboratory,Department of Materials Science and Engineering,College of Science and Engineering,MOE Engineering Research Center of Artificial Organs and Materials,Ji′nan University,Guangzhou 510632)
  • Received:2008-10-17 Revised:2008-12-24 Published:2009-10-10 Online:2009-10-10

PDF

2570

被引次数

7

摘要：

在微波辅助下，以辛酸亚锡为催化剂、壳聚糖(CS)为大分子引发剂引发消旋丙交酯（D,L-LA）本体开环聚合制备了壳聚糖接枝聚乳酸共聚物。通过正交实验研究了微波功率、催化剂用量、反应温度和反应时间对聚合反应的影响，确定了最佳合成条件。并通过红外光谱、元素分析、核磁共振氢谱、X-射线衍射和热分析对接枝共聚物的结构与性能进行了表征。结果表明，在微波条件下，能快速、有效地合成预定结构的壳聚糖接枝聚乳酸共聚物；聚乳酸支链的引入，有效削弱了壳聚糖分子间和分子内较强的氢键作用，与相应的壳聚糖比较，共聚物的结晶性能下降，热分解温度降低；原料配比对共聚物的结构与性能有显著影响，随nD,L-LA/nCS糖环数值增大，共聚物中平均乳酰单元数逐渐增大，共聚物的结晶性能、起始分解温度逐渐下降。

关键词: 微波合成，壳聚糖，聚乳酸，接枝共聚物

Abstract:

Using a new method—microwave-irradiation to get the chitosan-graft-poly(D,L-lactide)(CS-g-PLA) copolymer, the graft copolymerization was carried out by ring opening polymerization using stannous octoat (Sn(Oct)2) as catalyst without any organic solvent. In order to find the best reaction condition, the effection of different condition in copolymerization were studied by the orthogonality experiment, including power of microwave, dosage of Sn(Oct)2, reaction time and temperature. And the graft copolymers were characterized by FTIR, 1H-NMR, DSC, X-RD and TG. The results showed that microwave-assisted ring-opening polymerization can obtain the CS-g-PLA copolymer successfully and raipdly.Compared with chitosan, the grafting copolymerization has destroyed the original crystallinity of chitosan, the products’ onset temperature of degradation and thermal stability descended. The feed ratio(D,L-lactide /aminoglucoside units molar ratio) had a strong influence on the structure and properties of CS-g-PLA copolymer, higher feed ratios led to graft copolymer with higher average degree of polymerization of polylactide branch chains, and the lower crystallinity and onset temperature of degradation.

Key words: microwave-assisted synthesis,chitosan,poly(D,L-lactide),graft copolymer

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