中华医学超声杂志

应用化学 ›› 2009, Vol. 26 ›› Issue (07): 762-765.

• 研究论文 • 上一篇    下一篇

1-[3’-(6’-苯甲酰基-N-烯丙基咔唑)]-1-丁酮肟-O-乙酸酯的合成和光引发性能

谢川1,冯岩1,李万舜2   

  1. 1. 四川大学化学工程学院
    2. 四川大学化工学院
  • 收稿日期:2008-07-10 修回日期:2008-09-27 出版日期:2009-07-10 发布日期:2009-07-10
  • 通讯作者: 谢川

Synthesis of 1-(6-benzoyl-9-allyl-9.H.-carbazol-3-yl)-butane-1-one oxime O-ethyrate and photoinitiability

  • Received:2008-07-10 Revised:2008-09-27 Published:2009-07-10 Online:2009-07-10

PDF

747

摘要： 以N－烯丙基咔唑为原料，经Fridel-Crafts酰化反应、成肟和酯化，得到目标化合物。通过正交试验研究了关键步骤Fridel-Crafts酰化，得到最佳反应条件：N-烯丙基咔唑用量为0.020mol，催化剂与原料摩尔比1.10，反应物摩尔比1.15， 25℃下反应4h，产率可达94.2%。目标产物的结构通过IR,UV, 1H NMR和元素分析进行表征。并初步测试其光引发性能。

关键词: 咔唑肟酯, 合成, 正交试验, 光引发性

Abstract: In this paper 1-(6-benzoyl-9-allyl-9.H.-carbazol-3-yl)-butane-1-one oxime O-ethyrate was synthesed by Friedel-Crafts acylation, oximation and esterification from N-allylcarbazole. As the key step of the synthesis, the Friedel-Crafts acylation was researched. The optimal operation conditions were dertermined by orthogonal experiment: 0.02mol N-allylcarbazol, mol ratio of catalyst (nAlCl3/nN－烯丙基咔唑)1.10, mol ratio of reactants(n苯甲酰氯/nN－烯丙基咔唑)1.15,for 3h at 25℃. The average yield was 94.2%. The structure of the target compound was characterized by 1HNMR, UV, IR and elemental analysis.Photoinitiability of the compound was investigated.

Key words: carbazol oxime ester, synthesis, orthogonal experiment, photoinitiability

网站版权 © 应用化学     本网站备案：吉ICP备12000082号