中华医学超声杂志

应用化学 ›› 1998, Vol. 0 ›› Issue (4): 41-44.

• 研究论文 • 上一篇    下一篇

钒取代杂多钨酸盐抗伪狂犬病病毒的活性

刘杰1, 涂长春2, 张茂林2, 侯世宽2, 王恩波1   

  1. 1. 东北师范大学化学系 长春 130024;
    2. 解放军农牧大学军事兽医研究所 长春
  • 收稿日期:1997-10-27 修回日期:1998-03-30 出版日期:1998-08-10 发布日期:1998-08-10
  • 基金资助:
    国家科委资助

Activity of Vanadium-substituted Heteropolytungstate to Antipseudorabies Virus

Liu Jie1, Tu Changchun2, Zhang Maolin2, Hou Shikuan2, Wang Enbo1   

  1. 1. Deprtment of Chemistry, Northeast Normal University, Changchun 130024;
    2. The Military Veterinary Institute, University of Agriculureand Animal Sciences, Changchun
  • Received:1997-10-27 Revised:1998-03-30 Published:1998-08-10 Online:1998-08-10

PDF

394

被引次数

17 | 1

摘要： 合成了10种钒取代的杂多钨酸盐,采用细胞培养法,测定了各化合物对兔肾(RK)细胞的毒性及在无毒浓度下,抗伪狂犬病病毒(PRV)的活性,结果表明,部分化合物在无毒浓度下,具有较强的抗伪狂犬病病毒的活性.其中3种化合物显示出相当高的效力和选择性,半有浓度为3.5～5.0mg/L,半中毒浓度在400～420mg/L之间,化合物的浓度在25mg/L时,对伪狂犬病病毒的抑制作用达70%～80%,病毒的感染滴度TCID50下降4个对数.对其构效关系以及抗病毒机理也作了初步探讨.

关键词: 钒取代杂多钨酸盐, 合成, 抗病毒活性, 伪狂犬病病毒

Abstract: Some vanadium-substituted hetropolytungstates were synthesized.Their toxicityto the cells of RK and activity to antipseudorabies virus at nontoxic concentrations were tested by cell-culture methods.The results showed that some of the compounds had high antiPRV activity at nontoxic concentration.Among them three had high antivirus and selectiveactivity with median effective concentration 3.2～5.0 mg/L and cell median toxicity concentration 400～420 mg/L.At concentration of the compounds 12.5 mg/L the inhibition toPRV was more than 70%～80%, while virus TCID50 values descended four log.The relationbetween the structure and activity has been discussed briefly.

Key words: vanadium-substituted heteropolytungstate, antivirus activity, pseudorabies virus

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