中华医学超声杂志

应用化学 ›› 1998, Vol. 0 ›› Issue (3): 51-54.

• 研究论文 • 上一篇    下一篇

3,6-二芳基-1,2,4-三唑并[3,4-b]-1,3,4-噻二唑化合物的合成

史海健1, 王忠义2, 史好新1   

  1. 1. 安徽师范大学化学系 芜湖241000;
    2. 中国科技大学化学系 合肥
  • 收稿日期:1997-10-21 修回日期:1998-03-16 出版日期:1998-06-10 发布日期:1998-06-10
  • 基金资助:
    安徽省自然科学基金和安徽省教委基金

Synthesis of 3,6-Diaryl-1,2,4-triazolo-1,3,4-thiadiazoles

Shi Haijian1, Wang Zhongyi2, Shi Haoxin 1   

  1. 1. Department of Chemistry, Anhui Normal University, Wuhu 241000;
    2. Department of Chemistry, China University of Science and Technology, Hefei
  • Received:1997-10-21 Revised:1998-03-16 Published:1998-06-10 Online:1998-06-10

PDF

412

被引次数

1

摘要： 3-芳基-4-氨基-5-巯基-1,2,4-三唑与芳酸在三氯氧磷的作用下合成了10个标题化合物,通过元素分析、红外光谱、核磁共振氢谱和质谱确证了它们的结构。对反应条件作了简略的讨论。部分化合物具有较强的生物活性。

关键词: 二芳基-三唑并[3`4-b]-噻二唑化合物, 合成, 生物活性

Abstract: Ten title compounds have been prepared by reacting equal mole of 3-aryl-4-amino-5-mercapto-1,2,4-triazoles and aryl carboxylic acids in the presence of phosphorus oxychloride at 98 ℃ for 4～6 h. The structures of the compounds have been characterized by elemental analysis, IR, 1H NMR and MS measurements. All the compounds were preliminary screened for antimicrobial activity against Staphylococcus aureus and Escherichia coli in 0.002% concentration. Some of the compounds exhibited a rather strong biological activity.

Key words: diaryl-triazolo[3,4-b]-thiadiazole, synthesis, biological activity

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