中华医学超声杂志

应用化学 ›› 1997, Vol. 0 ›› Issue (2): 45-49.

• 研究论文 • 上一篇    下一篇

含O-(1,2,2,2-四氯)乙基-O-取代苯基硫逐磷酰胺酯的合成、结构表征和生物活性

李盛彪1, 黄世强1, 何良年2, 黄天宝2, 周青春2, 张景龄2   

  1. 1. 湖北大学化学系, 武汉 430062;
    2. 华中师范大学有机合成研究所, 武汉
  • 收稿日期:1996-08-28 修回日期:1996-11-06 出版日期:1997-04-10 发布日期:1997-04-10
  • 基金资助:
    国家自然科学基金

Synthesis, Characterization and Biological Activity of O-(1,2,2,2 tetrachloro)ethyl-i>O-Substituted Phenyl-Phosphoramidothionates

Li Shengbiao1, Huang Shiqiang1, He Liangnian2, Huang Tianbao2, Zhou Qingchun2, Zhang Jinling2   

  1. 1. Department of Chemistry, Hubei University, Wuhan 430062;
    2. Institute of Organic Synthesis, Central China Normal University, Wuhan
  • Received:1996-08-28 Revised:1996-11-06 Published:1997-04-10 Online:1997-04-10

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摘要： 以取代的苯氧基替代烷氧基,合成了21种新的O-(1,2,2,2-四氯)乙基-O-取代苯基硫逐磷酰胺酯。通过元素分析、IR、1H NMR、31PNMR和MS对化合物进行鉴定。O-(1,2,2,2-四氯)乙基硫逐磷酰肼在碱性条件下可容易地生成1,3,4,2-口恶二唑磷杂环戊烷。并确定了其质谱裂解机制。生物活性普筛结果表明,个别化合物具有高效防治根结线虫活性。

关键词: 硫逐磷酰胺酯, 合成, 生物活性, 口恶二唑磷杂环

Abstract: Twenty one new O-(1,2,2,2 tetrachloro)ethyl O-ubstituted phenyl phosphoramidothionates were synthesized and their structures were characterized through IR, NMR(1H、 31P)and MS. The O-(1,2,2,2 tetrachloro)ethyl thiophosphoric hydrazides could be transferred into 1,3,4,2-oxadiazaphospholanes under alkaline condition. The biological activity of the products was also tested and some compounds showed a high activity against nematode.

Key words: phosphoramidothionate, synthesis, biological activity, oxadiazaphospholane

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