中华医学超声杂志

应用化学 ›› 1996, Vol. 0 ›› Issue (4): 34-37.

• 研究论文 • 上一篇    下一篇

2H－4,9－二甲基呋喃并[2′,3′:5,6]萘并[1,2－b]吡喃－2－酮的合成、光谱及DNA嵌入活性

陶志福1, 钱旭红1, 唐军1, 陈馥衡2   

  1. 1. 华东理工大学药物化工研究所 上海 200237;
    2. 北京农业大学应用化学系 北京
  • 收稿日期:1995-10-17 修回日期:1995-12-18 出版日期:1996-08-10 发布日期:1996-08-10
  • 基金资助:
    国家自然科学基金;国家教委重点博士点基金;优秀年轻教师基金

Synthesis,Spectra and DNA Intercalation of 2H-4,9-Dimethylfuro[2′,3′:5,6] naphtho [1,2-b] pyron-2-one

Tao Zhifu1, Qian Xuhong1, Tang Jun1, Chen Fuheng2   

  1. 1. Institute of Pesticides and Pharmaceuticals, East China University of Science and Technology, Shanghai 200237;
    2. Department of Applied Chemistry, Beijing Agricultural University, Beijing
  • Received:1995-10-17 Revised:1995-12-18 Published:1996-08-10 Online:1996-08-10

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摘要： 以萘并吡喃酮为原料,通过3种方法合成了标题化合物,其结构经1H NMR,IR,MS及元素分析确证,并考察对小牛胸腺DNA的嵌入活性。

关键词: 萘并吡喃酮, DNA嵌入, 合成, 光谱

Abstract: The title compound was synthesized by three methods from naphthopyrone. The structures of this compound and its precursors were fully characterized by 1H NMR, MS, IR and elemental analysis.Its DNA-intercalative activity was investigated in DMSO-Tris HCl system by fluorescence quenching technique and the apparent Scatchard binding constant was estimated. Results showed that it efficiently intercalated into DNA.The spectral properties and DNA-intercalative activity have been compared with those of its analogues.

Key words: naphthopyrones, DNA intercalation activity, synthesis, spectrum

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