中华医学超声杂志

应用化学 ›› 1993, Vol. 0 ›› Issue (3): 42-46.

• 研究论文 • 上一篇    下一篇

固-液相转移催化法合成腺嘌呤类药物

王植材, 林电伟, 郑其煌   

  1. 中山大学化学系 510275 广州
  • 收稿日期:1992-07-14 修回日期:1992-12-08 出版日期:1993-06-10 发布日期:1993-06-10

SYNTHESIS OF ADENINE DERIVATIVES BY SOLID-LIQUID PHASE TRANSFER CATALYSIS

Wang Zhicai, Lin Dianwei, Zheng Qihuang   

  1. Department of Chemistry, Zhongshan University, 510275 Guangzhou
  • Received:1992-07-14 Revised:1992-12-08 Published:1993-06-10 Online:1993-06-10

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340

摘要： 本文报道固-液相转移催化法合成降血脂药香菇嘌呤(Ⅰ)和香菇嘌呤乙酯(la)、广谱抗病毒剂β-腺嘌呤基丙酸(2)和β-腺嘌呤基丙酸乙酯(2a)。研究了影响产率的不同因素。实验表明:聚乙二醇(PEG)是合适的固-液相转移催化剂。

关键词: 腺嘌呤类药物, 固-液相转移催化法, 合成

Abstract: Adenine derivatives as pharmaceuticals-eritadenine (1), ethyl 4-(6-amino-9H-purine-9-yl)-2(R), 3(R)-dihydroxybutyrate (1a),β-adenylpropionic acid (2) and ethyl β-adenylpropionate (2a) have been synthesized by solid-liquid phase transfer eatalysis. The effects of reaction conditions on the yields were studied. The results showed that PEG is a good phase transfer catalyst for the reaction.

Key words: adenine derivative, solid-liquid phase transfer catalysis, synthesis

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