中华医学超声杂志

应用化学 ›› 1993, Vol. 0 ›› Issue (2): 73-74.

• 研究简报 • 上一篇    下一篇

一锅反应合成1-三甲硅氧基烯丙基膦酸酯

李中华, 朱传方, 赵永镇   

  1. 华中师范大学化学系 430070 武汉
  • 收稿日期:1992-03-11 修回日期:1992-05-04 出版日期:1993-04-10 发布日期:1993-04-10

AN ONE-POT SYNTHESIS OF 1-TRIMETHYLSILOXY ALLYLPHOSPHONATES

Li Zhonghua, Zhu Chuanfang, ZhaoYongzhen   

  1. Department of Chemistry, Central China Normal University, 430070 Wuhan
  • Received:1992-03-11 Revised:1992-05-04 Published:1993-04-10 Online:1993-04-10

PDF

325

被引次数

1

摘要： 1-三甲硅氧基膦酸酯是一类具有显著生物活性的有机硅磷化合物。具有药效长、毒性低等特点,采用含P—O—Si键的亚磷酸酯与羰基化合物反应的方法进行合成,反应条件温和,产率比较高,但需要先制备化学性质活泼的含硅基亚磷酸酯,而且反应要在惰性气体下进行,实施有所不便。本文直接采用三烷基亚磷酸酯(1)、α、β-不饱和醛(2)与三甲基氯硅烷进行一锅反应合成1-三甲硅氧基烯丙基麟酸酯(3a～3f)。

关键词: 亚磷酸酯, 膦酸酯, 合成

Abstract: 1-Trimethylsiloxy allylphosphonates (3a-f) were synthesized by reacting phosphites (1), α, β-unsaturated aldehydes (2) and trimethylchlorosilane in one pot. The synthesis was carried out under a very mild conditions and was easy to operate. The structures of the phesphonates obtained were confirmed by IR, 1H, 31P NMR and MS.

Key words: phosphite, phosphonate, synthesis

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