中华医学超声杂志

应用化学 ›› 1993, Vol. 0 ›› Issue (1): 104-106.

• 研究简报 • 上一篇    下一篇

1-苯乙酰基-4-芳酰基氨基硫脲的合成及其在碱催化下的环化反应

冯小明1, 陈荣1, 张自义2   

  1. 1. 西南师范大学化学系 630715 重庆;
    2. 兰州大学化学系 兰州
  • 收稿日期:1992-01-27 修回日期:1992-06-25 出版日期:1993-02-10 发布日期:1993-02-10

SYNTHESIS OF 1-PHENYLACETYL-4-AROYLTHIOSEMICAR-BAZIDES AND THEIR CYCLIZATION

Feng Xiaoming1, Chen Rong1, Zhang Ziyi2   

  1. 1. Department of Chemistry, Southwest Normal University, 630715 Chongqing;
    2. Department of Chemistry, Lanzhou University, Lanzhou
  • Received:1992-01-27 Revised:1992-06-25 Published:1993-02-10 Online:1993-02-10

PDF

632

被引次数

2

摘要： 1-酰基-4-芳基氨基硫脲类化合物在碱性条件下环化为具有广泛生物活性的3-取代基-4-芳基-1,2,4-三唑啉-5-硫酮的反应报道甚多,但1,4-位都含羰基的酰氨基硫脲在碱性条件下环化反应迄今报道较少。我们曾研究了1-[5-(α-萘)-2H-四唑-2-乙酰基]-4-芳酰基氨基硫脲和1-(α-萘乙酰基)-4-芳酰基氨基硫脲在碱催化下环化为3-取代基-4-芳酰基-1,2,4-三唑啉-5-硫酮的反应,它们在低浓度下均有一定的生物活性。本文研究了1-苯乙酰基-4-芳酰基氨基硫脲1a～m在1mol/L K2CO3溶液催化下的环化反应,得到环化产物3-苄基-4-芳酰基-1,2,4-三哇琳-5-硫酮2a～m

关键词: 酰氨基硫脲, 三唑啉硫酮, 合成, 杀菌剂

Abstract: A series of 1-phenylaeetyl-4-aroylthiosemicarbazides (1) were synthesized by the reaction of phenylacetylhydrazine with aroyl isothiocyanates. Some of 3-benzyl-4-aroyl-1,2, 4-triazoline-5-thione (2) were obtained in good yields through the cyclization of 1 in 1mol/LK2CO3 solution. The structures of all compounds prepared were characterized by elemental analysis,IR,1H NMR and MS.The preliminary experiments showed that compounds 1 and 2 possess some inhibiting activity on B. substilis.

Key words: acylthiosemicarbazide, triazolinethione, synthesis, bactericide

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