中华医学超声杂志

应用化学 ›› 1992, Vol. 0 ›› Issue (4): 117-119.

• 研究简报 • 上一篇    下一篇

合成光学活性樟脑

李允隆, 陈庆之, 杨国丽, 曹舒林, 蔡晓军, 刘尧权   

  1. 中国科学院广州化学研究所, 广州 510650
  • 收稿日期:1992-01-06 修回日期:1992-03-09 出版日期:1992-08-10 发布日期:1992-08-10
  • 基金资助:
    国家自然科学基金

PREPARATION OF OPTICALLY ACTIVE CAMPHOR

Li Yunlong, Chen Qingzhi, Yang Guoli, Cao Shulin, Cai Xiaojun, Liu Yaoquan   

  1. Guangzhou Institute of Chemistry, Academia Sinica, Guangzhou 510650
  • Received:1992-01-06 Revised:1992-03-09 Published:1992-08-10 Online:1992-08-10

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摘要： 目前按所谓“四步法”生产的[1,2]合成樟脑是消旋的。天然樟脑是光学活性的,大多数为右旋体。左旋天然樟脑较为稀少。藤原羲人[3],松原羲治[4]等曾报道合成光学活性樟脑,其中龙脑脱氢反应是在有机溶剂的存在下进行的,产物的光学纯度为原料的70%左右。本文报道的合成光学活性樟脑方法,龙脑在固定床流通式反应器中进行脱氢,不加任何溶剂,产品樟脑可保持与龙脑相同的光学纯度。

关键词: 樟脑, 光学活性, 脱氢, 合成

Abstract: Optically active camphor(3) was synthesized in rational yield via dehydrogenation of n-borneol (2α) which was a natural product or obtained via hydration of 2-pinene(1) by one step. The dehydrogenation was carried out in the presence of Zn-laden catalyst, in gasphase,with6ut use of any solvents. The camphor obtained possesses almost the same optical pureness as its starting material-natural n-borneol or 2-pinene.

Key words: camphor, optical activity, dehydrogenation, synthesis

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