中华医学超声杂志

应用化学 ›› 1992, Vol. 0 ›› Issue (3): 31-36.

• 研究论文 • 上一篇    下一篇

2-羰基丙酸(吡啶-4-甲酰基)腙稀土双核配合物的合成、表征及抗肿瘤活性

杨正银, 王流芳, 吴集贵, 李兴玉   

  1. 兰州医学院, 兰州 730000
  • 收稿日期:1991-03-09 修回日期:1991-08-20 出版日期:1992-06-10 发布日期:1992-06-10
  • 基金资助:
    国家自然科学基金

SYNTHESIS,CHARACTERIZATION AND ANTITUMOR ACTIVITY OF COMPLEXES OF 2-CARBONYLPROPIONYL (PYRIDINE-4-FORMYL) HYDRAZONE WITH RARE EARTHS

Yang Zhengyin, Wang Liufang, Wu Jigui, Li Xingyu   

  1. Department of Chemistry, Lanzhou University, Lanzhou 73000
  • Received:1991-03-09 Revised:1991-08-20 Published:1992-06-10 Online:1992-06-10

PDF

522

摘要： 从2-羰基丙酸(吡啶-4-甲酰基)腙(H2PPFH)合成了13种组成为RE2(PPFH)3·nH2O(RE=La-Yb,n=2～3)的稀土腙固体配合物。通过红外、紫外、元素分析,电导及核磁共振谱等方法对其进行了表征。经药理实验发现配合物Eu2(PPFH)3·3H2O具有抗肿瘤活性。

关键词: 腙, 稀土配合物, 抗肿瘤活性, 合成

Abstract: 2-Carbonylpropionyl (pyridine-4-formyl) hydrazone (H2PPPH)has been synthesized by a simple method. It is a weak acid, and the complexation was carried out in the water solution of rare earth carbonates. 13 complexes have general composition of RE2(PPFH)3·nH2O (RE=La～Yb, n=2～3). The structures and properties of the complexes were characterized by elemental analysis, IR, UV spectra, TGA-DTA, molar conductance and 1H NMR measuramcnts. Eu2(PPFH)3·3H2O was showed to have a certain antitumor activity.

Key words: 2-carbonylpropionic acid, isonicotinyl hydrazine, hydrazone, rare earth, complex, antitumor activity, synthesis

网站版权 © 应用化学     本网站备案：吉ICP备12000082号