无溶剂无催化条件下一锅合成芳酰基腈化合物

doi:10.3724/SP.J.1095.2014.30524

摘要/Abstract

摘要： 无溶剂无催化剂条件下，以芳香酸、二氯亚砜和铁氰化钾为原料，经氯化、氰化两步一锅合成了一系列芳酰基腈化合物。考察了氰化过程中反应温度、反应时间对产率的影响。实验结果表明，其最佳反应条件为：反应温度为180 ℃，反应时间为2 h，产物收率达71%~92%。产物经IR、1H NMR和13C NMR分析确认。本方法具有工艺操作简单、产率高、无溶剂无催化和环境友好等优点。

关键词: 一锅法, 无溶剂, 芳酰氯, 芳酰基腈, 合成

Abstract: A series of aroyl cyanides was synthesized by nucleophilic substitution reactions of aromatic acids with thionyl chloride and potassium ferricyanide in one-pot under solvent-free and catalyst-free conditions. The effects of the reaction temperature and time on the yield of the products were investigated. The yields of aroyl cyanides were up to 71%~92% when the reactions were performed at 180 ℃ for 2 h. The structures of the products were confirmed by IR, 1H NMR and 13C NMR spectroscopy. This method has advantages of simple work-up procedure, high yield, and eco-friendly solvent-free and catalyst-free conditions.

Key words: one-pot, solvent-free, aromatic acyl chloride, aroyl cyanides, synthesis

中图分类号:

O623.5

赵宙兴. 无溶剂无催化条件下一锅合成芳酰基腈化合物[J]. 应用化学, DOI: 10.3724/SP.J.1095.2014.30524.

ZHAO Zhouxing. One-pot Synthesis of Aroyl Cyanides Under Solvent-free and Catalyst-free Conditions[J]. Chinese Journal of Applied Chemistry, DOI: 10.3724/SP.J.1095.2014.30524.

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